Calcified Tissue Research

, Volume 23, Issue 1, pp 103–112 | Cite as

Movement of125I albumin and125I polyvinylpyrrolidone through bone tissue fluid

  • Maureen Owen
  • C. R. Howlett
  • J. T. Triffitt
Original Papers


The passage of tissue fluid through cortical bone has been investigated using radioactively labelled macromolecules as markers. The results suggest that in the cortex of young rabbit femur the movement of tissue fluid is in the same net direction as blood, mainly from the endosteal to the periosteal surface.

Some albumin is incorporated from extravascular tissue fluid into calcified matrix at sites of bone formation. Polyvinylpyrrolidone, average molecular weight 35,000 is able to pass through extravascular tissue fluid in bone but isnot incorporated into calcified matrix. In rabbits made vitamin D deficient, much less albumin is retained in regions of bone formation than is the case with controls. Albumin adsorbs to the surface of calcium phosphate precipitates and it is suggested that this mechanism may be mainly responsible for its incorporation into bone.


Albumin Polyvinylpyrrolidone Tissue fluid Bone 


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Copyright information

© Springer-Verlag 1977

Authors and Affiliations

  • Maureen Owen
    • 1
  • C. R. Howlett
    • 1
  • J. T. Triffitt
    • 1
  1. 1.Bone Research Laboratory, Nuffield Department of Orthopaedic SurgeryUniversity of Oxford, Nuffield Orthopaedic CentreOxfordUK

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