, Volume 41, Issue 6, pp 732–734 | Cite as

Isoprenaline-like effects of the phosphodiesterase inhibitor 3-isobutyl-1-methylxanthine on mechanical, biochemical and electrophysiological parameters in the mammalian heart

  • R. Brückner
  • S. Gramann
  • M. Nose
  • W. Schmitz
  • H. Scholz
Short Communications Biochemistry and Biophysics, Metabolism, Neurobiology, Pharmacology


The phosphodiesterase inhibitor 3-isobutyl-1-methylxanthine (IBMX) mimicked the effects of isoprenaline on the force of contraction, the cAMP content and the slow Ca++ inward current (Isi) in isolated guinea pig papillary muscles. The results support the hypothesis that phosphodiesterase inhibitors and β-adrenoceptor agonists exert their positive inotropic effects by increasing Isi via the common mediator cAMP.

Key words

3-Isobutyl-1-methylxanthine guinea pig heart phosphodiesterase inhibitor isoprenaline slow inward current positive inotropic effect cAMP cGMP 


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Copyright information

© Birkhäuser Verlag Basel 1985

Authors and Affiliations

  • R. Brückner
    • 1
  • S. Gramann
    • 1
  • M. Nose
    • 1
  • W. Schmitz
    • 1
  • H. Scholz
    • 1
  1. 1.Abteilung Allgemeine Pharmakologie, Universitäts-Krankenhaus EppendorfUniversität HamburgHamburg 20Germany

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