Pediatric Radiology

, Volume 23, Issue 2, pp 140–142 | Cite as

Transfusional hemosiderosis in sickle cell anemia: Another cause of an echogenic pancreas

  • M. A. Flyer
  • J. O. Haller
  • R. Sundaram


We report four sickle cell anemia patients who have received multiple blood transfusions and have been non-compliant on Desferal chelation therapy. Abdominal ultrasonography demonstrated an echogenic pancreas in all four patients. Magnetic resonance imaging in three patients revealed decreased signal intensity in all sequences in the pancreas and liver. All four patients had marked iron deposition on liver biopsy. To our knowledge, increased echogenicity of the pancreas secondary to hemosiderosis (2o hemochromatosis) in sickle cell patients has not been reported in the radiologic literature.


Liver Biopsy Sickle Cell Anemia Sickle Cell Hemochromatosis Iron Deposition 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 1.
    O'Brien PT (1977) Iron overload: clinical and pathologic aspects in pediatrics. Semin Hematol 14: 115–123PubMedGoogle Scholar
  2. 2.
    Marks WM, Filly RA, Callen PW (1980) Ultrasound evaluation of normal pancreatic echogenicity and its relationship to fat deposition. Radiology 137: 475–479PubMedGoogle Scholar
  3. 3.
    Filly RA, London SS (1979) The normal pancreas: acoustic characteristics and frequency of imaging. J Clin Ultrasound 7: 121–124PubMedGoogle Scholar
  4. 4.
    Worthen NJ, Beabeau D (1982) Normal pancreatic echogenicity: relation to age and body fat. AJR 139: 1095–1098PubMedGoogle Scholar
  5. 5.
    Daneman A, Gaskin K, Martin DJ, Cutz E (1983) Pancreatic changes in cystic fibrosis: CT and sonographic appearances. AJR 141: 653–655PubMedGoogle Scholar
  6. 6.
    Bastid C, Peitri H, Sahel J, Rizzo L, Sarles H (1986) Aspects echographiques du pancreas au cours de l'hemochromatose. Acta Gastroenterol Belgica IL: 512–516Google Scholar
  7. 7.
    Schneider K, Harms K, Fendel H (1987) Increased echogenicity of the pancreas in infants and children: the white pancreas. Eur J Pediatr 146: 508–511PubMedGoogle Scholar
  8. 8.
    Erhmann R, Hausdorf G, Landbeck G (1983) Pancreatic sonography in thalassemia major. Klin Pädiatr 195: 97–99Google Scholar
  9. 9.
    Patel S, Bellon EM, Haaga J, Park CH (1980) Fat replacement of the exocrine pancreas. AJR 135: 843–845PubMedGoogle Scholar
  10. 10.
    Brasch RC, Wesbey GE, Gooding CA, Koerper MA (1984) Magnetic resonance imaging of transfusional hemosiderosis complicating thalassemia major. Radiology 150: 767–771PubMedGoogle Scholar
  11. 11.
    Suda K (1985) Hemosiderin deposition in the pancreas. Arch Pathol Lab Med 109: 996–999PubMedGoogle Scholar
  12. 12.
    Ley TJ, Griffith P, Neinhuis AW (1982) Transfusion haemosiderosis and chelation therapy. Clin Haematol 11: 437–459PubMedGoogle Scholar

Copyright information

© Springer-Verlag 1993

Authors and Affiliations

  • M. A. Flyer
    • 1
  • J. O. Haller
    • 1
  • R. Sundaram
    • 2
  1. 1.Department of RadiologyState University of New York, Health Science Center at BrooklynBrooklynUSA
  2. 2.Department of PediatricsThe Long Island College HospitalBrooklynUSA

Personalised recommendations