Advertisement

Pediatric Radiology

, Volume 23, Issue 4, pp 276–280 | Cite as

MIBG detection of hepatic neuroblastoma: Correlation with CT, US and surgical findings

  • D. A. Dessner
  • M. A. DiPietro
  • B. L. Shulkin
Article

Abstract

Metaiodobenzylguanidine (MIBG) imaging is used in the diagnosis, staging and follow-up of virtually every case of neuroblastoma seen at our institution. Normal sites of MIBG uptake include the liver and therefore difficulties have been predicted and encountered in the diagnosis of hepatic neuroblastoma due to inability to separate abnormally increased tracer deposition from normal hepatic activity. We reviewed every MIBG (I123 and I131) study performed at our pediatric hospital over a 4 year period encompassing 88 patients, 67 of whom had biopsy proven neuroblastoma. Hepatic findings on MIBG studies were compared with concurrent abdominal CT and US studies in all 67 patients. The clinical records of all patients with abnormal MIBG scans or abnormal CT or US studies of the liver were also reviewed. Eight patients were found to have abnormal liver findings on one or more imaging studies (MIBG, CT, or US). There were 3 true positive MIBG studies, one of which was an early study in a patient who later went on to have one of the false positive studies. Two patients had false positive MIBG scans for liver neuroblastoma. MIBG failed to detect liver involvement in 4 patients.

Keywords

Neuroblastoma Pediatric Hospital Surgical Finding Liver Involvement MIBG Uptake 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    Shulkin BL, Shapiro B (1990) Radioiodinated metaiodobenzylguanidine (MIBG) in the management of neuroblastoma. In: Pochedly C (ed) Neuroblastoma tumor biology and therapy. CRC Press, Ann Arbor, pp 171–198Google Scholar
  2. 2.
    Geatti O, Shapiro B, Sisson JC et al (1985)131I-Metaiodobenzylguanidine (131I-MIBG) scintigraphy for the localization of neuroblastoma: preliminary experience in 10 cases. J Nucl Med 26: 736PubMedGoogle Scholar
  3. 3.
    Nakajo M, Shapiro B, Copp J et al (1983) The normal and abnormal distribution of the adrenomedullary imaging agent M[I131] iodobenzylguanidine (131-I-MIBG) in man: evaluation by scintigraphy. J Nucl Med 24:672PubMedGoogle Scholar
  4. 4.
    Lumbroso JD, Guermazi F, Hartman O et al (1988) Metaiodobenzylguanidine (MIBG) scans in neuroblastoma: sensitivity and specificity. A review of 115 scans. In: Advances in neuroblastoma research 2, Alan R Liss, pp 689–705Google Scholar

Copyright information

© Springer-Verlag 1993

Authors and Affiliations

  • D. A. Dessner
    • 1
    • 2
  • M. A. DiPietro
    • 1
    • 2
  • B. L. Shulkin
    • 1
    • 2
  1. 1.Departments of Radiology (Section of Pediatric Radiology)University of Michigan HospitalsAnn ArborUSA
  2. 2.Internal Medicine (Division of Nuclear Medicine)University of Michigan HospitalsAnn ArborUSA

Personalised recommendations