Abstract
Computerized tomographic scanning of the brain was performed in 26 infants with Infantile spasms. Majority of the patients, 18 (69%) had some abnormality. Changes noted were cerebral atrophy in 12, calcifications in 5 and dysgenesis of the corpus callosum in 3 patients. One infant each had porencephaly, hydrocephalus and cavum septum pellucidum. Five patients had more than one abnormality simultaneously. Three infants had progressively worsening atrophy on ACTH therapy. Patients with infantile spasms, without any physical or neurological abnormality, are unlikely to have any abnormalities on brain CT scanning (p=<0.005).
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West WJ (1841) On a peculiar form of infantile convulsions (letter). Lancet I: 724
Vasquez HJ, Turner M (1951) Epilepsia in flexion generallizada. Arch Argent Pediatr 35: 111
Gibbs EL, Fleming MM, Gibbs FA (1954) Diagnosis and prognosis of hypsarrhythmia and infantile spasms. Pediatrics 13: 66
Cruse RP (1984) Infantile spasms. Cleve Clin Q 51: 273
Riikonen R (1984) Infantile spasms: modern practical aspects. Acta Pediatr Scand 73: 1
Kurokawa T, Goya N, Fukuyama Y, Suzuki M, Seki T, Ohtahara S (1980) West syndrome and Lennox-Gestaut Syndrome: a survey of natural history. Pediatrics 65: 81
Singer WD, Haller JS, Sullivan LR, Wolpert S, Mills C, Rabe EF (1982) The value of neuroradiology in infantile spasms. J Pediatr 100: 47
Gastaut T, Gastaut JL, Regis H, Bernard R, Pinsard N, Saint-Jean M, Roger J, Dravet C (1978) Computerized tomography in the study of West's syndrome. Develop Med Child Neurol 20: 21–27
Chevrie JJ, Aicardy J (1986) The Aicardy syndrome. In: Pedley TA, Meldrum BS (eds) Recent advances in epilepsy, Vol 3. Churchill Livingstone, New York, p 189
Okuno T, Ito M, Konishi Y, Yoshioka M, Nakano Y (1980) Cerebral atrophy following ACTH therapy. J Comput Assist Tomogr 4: 20
Satoh J, Takeshige H, Hara H, Fukuyama Y (1982) Brain shrinkage and subdural effusion associated with ACTH administration. Brain Development 4: 13
Glaze DG, Hrachovy RA, Frost JD, Zion TE, Bryan N (1986) Computed tomography in infantile spasms: effects of hormonal therapy. Pediatr Neurol 2: 23
Deonna T, Voumard C (1979) Reversible cerebral atrophy and corticotrophin. Lancet II: 207
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Mahdi, A.H., Yohannan, M.D., Patel, P.J. et al. Computerized tomography of brain in infantile spasms (West syndrome). Pediatr Radiol 21, 9–11 (1990). https://doi.org/10.1007/BF02010804
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DOI: https://doi.org/10.1007/BF02010804