Pediatric Radiology

, Volume 20, Issue 1–2, pp 76–79 | Cite as

Physeal involvement in chronic recurrent multifocal osteomyelitis

  • D. Manson
  • D. M. Wilmot
  • S. King
  • R. M. Laxer


Chronic recurrent multifocal osteomyelitis is a recently recognized disease characterized by remissions and exacerbations of multiple bone lesions which radiographically and pathologically have the appearance of hematogenous osteomyelitis. No consistent etiology can be identified, and antimicrobial agents seem to have no beneficial effect. A review of the appearances of imaging modalities and the clinical and pathologic manifestations is undertaken in seven cases of CRMO. No therapeutic regimen resulted in consistent clinical or radiographic improvement. We suggest the sequelae of this process are not as benign as previously reported.


Public Health Beneficial Effect Imaging Modality Antimicrobial Agent Osteomyelitis 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 1.
    Probst FP, Bjorksten B, Gustavson KH (1978) Radiological aspect of chronic recurrent multifocal osteomyelitis. Ann Radiol (Paris) 21: 115Google Scholar
  2. 2.
    Giedion A, Holthusen W, Masel IF, Vischer D (1972) Subacute and chronic “symmetrical” osteomyelitis. Ann Radiol (Paris) 15: 329Google Scholar
  3. 3.
    King S, Laxer R, Manson D, Gold R (1987) Chronic recurrent multifocal osteomyelitis: a noninfectiouis inflammatory process. Pediatr Infect Dis J 6: 907PubMedGoogle Scholar
  4. 4.
    Laxer R, Shore A, Manson D, King S, Silverman E, Wilmot D (1988) Chronic recurrent multifocal osteomyelitis and psoriasis-report of a new association and review of related disorder.Google Scholar
  5. 5.
    Gustavson KH, Wilbrand HF (1974) Chronic symmetric osteomyelitis. Acta Radiol [Diagn] (Stockh) 15: 551Google Scholar
  6. 6.
    Murray S, Kehl D (1984) Chronic recurrent multifocal osteomyelitis. J Bone Joint Surg [Am] 66: 1110Google Scholar
  7. 7.
    Meller Y, Yagupsky P, Elitser Y, Inbar-Ianay I, Bar-Ziv J (1984) Chronic multifocal symmetrical osteomyelitis. Am J Dis Child 138: 349PubMedGoogle Scholar
  8. 8.
    Probst FP (1976) Chronic multifocal cleido-metaphyseal osteomyelitis of childhood. Acta Radiol [Diagn] (Stockh) 17: 531Google Scholar
  9. 9.
    Solheim LF, Paus B, Liverud K, Stoen E (1980) Chronic recurrent multifocal osteomyelitis. Acta Orthop Scand 51: 37PubMedGoogle Scholar
  10. 10.
    Kozlowski K, Masel J, Harbison S, Yu J (1983) Multifocal chronic osteomyelitis of unknown etiology. Pediatr Radiol 13: 130PubMedGoogle Scholar
  11. 11.
    Weiner MD, Newbold RG, Merten DF (1986) Chronic recurrent multifocal osteomyelitis. AJR 146: 87PubMedGoogle Scholar
  12. 12.
    Bjorksten B, Boquist L (1980) Histopathological aspects of chronic recurrent multiofocal osteomyelitis. J Bone Joint Surg [Br] 62: 376Google Scholar
  13. 13.
    Brown T, Wilkonson R (1988) Chronic recurrent multifocal osteomyelitis. Radiology 166: 493PubMedGoogle Scholar

Copyright information

© Springer-Verlag 1989

Authors and Affiliations

  • D. Manson
    • 1
  • D. M. Wilmot
    • 2
  • S. King
    • 3
  • R. M. Laxer
    • 4
  1. 1.Department of RadiologyMcMaster UniversityHamiltonCanada
  2. 2.Department of Radiology, Associate of The Arthritis SocietyThe Hospital for Sick ChildrenTorontoCanada
  3. 3.Department of Infectious Diseases, Associate of The Arthritis SocietyThe Hospital for Sick ChildrenTorontoCanada
  4. 4.Division of Immunology, Department of Paediatrics, Associate of The Arthritis SocietyThe Hospital for Sick ChildrenTorontoCanada

Personalised recommendations