Skip to main content

Advertisement

SpringerLink
Log in

Comparison of radiolabeled monoclonal antibody and magnetic resonance imaging in the detection of metastatic neuroblastoma in bone marrow: preliminary results

  • Originals
  • Published:
Pediatric Radiology Aims and scope Submit manuscript

Abstract

Magnetic resonance imaging (MRI) was compared with iodine-131-labeled monoclonal antibody scanning for ability to detect bone marrow metastases in the spine, pelvis, and femurs of children with disseminated neuroblastoma. The five patients in this study had received high-dose chemotherapy and radiation, either with (N=2) or without (N=3) bone marrow transplants. MRI disclosed marrow abnormalities at all sites detected with the radiolabeled antibody, which is highly specific for neuroblastoma. However, several diffuse and multifocal marrow changes apparent on MR scans were not present on scintigrams, indicating that MRI is probably less specific than monoclonal antibody imaging. Both methods were more useful than conventional radiography, computed tomography, and99mTc-MDP bone scans for identifying sites of marrow involvement by neuroblastoma.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Cheung N-K V, Saarinen U, Neely J, Strandjord S, Warkentin PI, Coccia PF (1985) Development of neuroblastoma (NB) monoclonal antibodies for potential utilization in diagnosis and therapy. In: Evans AE (ed) Advances in neuroblastoma research, 50. Liss, New York

    Google Scholar 

  2. Cheung N-K V, Neely JE, Landmeier B, Nelson D, Miraldi F (1987) Targeting of ganglioside GD2 monoclonal antibody to neuroblastoma. J Nucl Med 28: 1577

    PubMed  Google Scholar 

  3. Miraldi FD, Nelson AD, Kraly C, Ellery S, Landmeier B, Coccia PF, Strandjord SE, Cheung N-KV (1986) Diagnostic imaging of human neuroblastoma with radiolabeled antibody. Radiology 161: 413

    PubMed  Google Scholar 

  4. Yeh S, Kushner BH, Sullivan M, Cheung NKV (1988) Radio-imaging of human neuroblastoma: a comparison between131I-3F8 and131I-MIBG. Presented at the annual meeting of the Society of Nuclear Medicine, San Diego, CA

  5. Daffner RH, Lupetin AR, Dash N, Deeb ZL, Sefczek RJ, Schapiro RL (1986) MRI in the detection of malignant infiltration of bone marrow. AJR 146: 353

    PubMed  Google Scholar 

  6. Moore SG, Gooding CA, Brasch RC, Ehman RL, Ringertz HG, Ablin AR, Matthay KK, Zoger S (1986) Bone marrow in children with acute lymphocytic leukemia: MR relaxation times. Radiology 160: 237

    PubMed  Google Scholar 

  7. Olson DO, Shields AF, Scheurich CJ, Porter BA, Moss AA (1986) Magnetic resonance imaging of the bone marrow in patients with leukemia, aplastic anemia, andlymphoma. Invest Radiol 21: 540

    PubMed  Google Scholar 

  8. Cohen MD, Klatte EC, Baehner, R, Smith JA, Martin-Simmerman P, Carr BE, Provisor AJ, Weetman RM, Coates T, Siddiqui A, Weisman SJ, Berkow R, McKenna S, McGuire WA (1984) Magnetic resonance imaging of bone marrow disease in children. Radiology 151: 715

    PubMed  Google Scholar 

  9. Mitchell DG, Rao VM, Dalinka M, Spritzer CE, Axel L, Gefter W, Kricun M, Steinberg ME, Kressel HY (1986) Hematopoietic and fatty bone marrow distribution in the normal and ischemic hip: new observations with 1.5-T MR imaging. Radiology 161: 199

    PubMed  Google Scholar 

  10. Hibi S, Todo S, Imashuku S, Miyazaki T (1987)131I-Metaiodobenzylguanidine scintigraphy in patients with neuroblastoma. Pediatr Radiol 17: 308

    PubMed  Google Scholar 

  11. Porter BA, Shields AF, Olson DO (1986) Magnetic resonance imaging of bone marrow disorders. Radiol Clin North Am 24: 269

    PubMed  Google Scholar 

  12. Kricun ME (1985) Red-yellow marrow conversion: Its effect on the location of some solitary bone lesions. Skeletal Radiol 14: 10

    PubMed  Google Scholar 

  13. Dooms GC, Fisher MR, Hricak H, Richardson M, Crooks LE, Genant HK (1985) Bone marrow imaging: magnetic resonance studies related to age and sex. Radiology 155: 429

    PubMed  Google Scholar 

  14. Zimmer WD, Berquist TH, McLeod RA, Sim FH, Pritchard DJ, Shives TC, Wold LE, May GR (1985) Bone tumors: magnetic resonance imaging versus computed tomography. Radiology 155: 709

    PubMed  Google Scholar 

  15. Fletcher BD, Kopiwoda SY, Strandjord SE, Nelson AD, Pickering SP (1985) Abdominal neuroblastoma: magnetic resonance imaging and tissue characterization. Radiology 155: 699

    PubMed  Google Scholar 

  16. Dietrich RB, Kangarloo H, Lenarsky C, Feig SA (1987) Neuroblastoma: the role of MR imaging. AJR 148: 937

    PubMed  Google Scholar 

  17. Mills AE, Bird AR (1986) Bone marrow changes in neuroblastoma. Pediatr Pathol 5: 225

    PubMed  Google Scholar 

  18. Lanir A, Aghai E, Simon JS, Lee RGL, Clouse ME (1986) MR imaging in myelofibrosis. J Comput Assist Tomogr 10: 634

    PubMed  Google Scholar 

Download references

Author information

Author notes

  1. N.-K. V. Cheung

    Present address: Department of Pediatrics, Memorial Sloan Kettering Cancer Center, 10021, New York, NY, USA

  2. B. D. Fletcher M.D.

    Present address: Department of Diagnostic Imaging, St. Jude Children's Research Hospital, 332 N. Lauderdale, P.O. Box 318, 38101-0318, Memphis, TN, USA

Authors and Affiliations

  1. Department of Radiology, University Hospitals of Cleveland, Cleveland, Ohio, USA

    B. D. Fletcher M.D. & F. D. Miraldi

  2. Department of Pediatrics, Rainbow Babies and Childrens Hospital, Cleveland, Ohio, USA

    N.-K. V. Cheung

Authors
  1. B. D. Fletcher M.D.
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. F. D. Miraldi
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. N.-K. V. Cheung
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Fletcher, B.D., Miraldi, F.D. & Cheung, NK.V. Comparison of radiolabeled monoclonal antibody and magnetic resonance imaging in the detection of metastatic neuroblastoma in bone marrow: preliminary results. Pediatr Radiol 20, 72–75 (1989). https://doi.org/10.1007/BF02010638

Download citation

  • Received:

  • Accepted:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF02010638

Keywords

Search

Navigation