Pediatric Radiology

, Volume 20, Issue 1–2, pp 61–66 | Cite as

Evaluation of potential practical oral contrast agents for pediatric magnetic resonance imaging

Preliminary observations
  • G. S. BissetIII


Development of a practical oral contrast agent for magnetic resonance imaging is necessary to improve differentiation of bowel from adjacent structures. In order to find a readily available, inexpensive, non-toxic, palatable solution for use in the pediatric population, several formulas, milk products and a common oral sedative were evaluated in vitro. T1, T2 and signal intensity measurements were performed on a 1.5 T system. Similac with standard iron proved to be a useful high signal intensity agent on multiple pulse sequences. Early in vivo experience in four normal volunteers indicates that this agent provides excellent delineation of the stomach and duodenum from contiguous viscera. Distal small bowel visualization is less predictable. Further clinical trials should confirm the utility of this solution, which contains a combination of iron salts and paramagnetic metallic ions.


Magnetic Resonance Imaging Small Bowel Milk Product High Signal Intensity Normal Volunteer 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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  1. 1.
    Wesbey GE, Brasch RC, Engelstad BL, Moss AA, Crooks LE, Brito AC (1983) Nuclear magnetic resonance contrast enhancement study of the gastrointestinal tract of rats and a human volunteer using non toxic oral iron solutions. Radiology 149: 175PubMedGoogle Scholar
  2. 2.
    Laniado M, Kornmesser W, Hamm B, Clauss W, Weinmann H, Felix R (1988) MR imaging of the gastrointestinal tract: value of Gd-DTPA. AJR 150: 817PubMedGoogle Scholar
  3. 3.
    Young IR, Clarke GJ, Bailes DR, Pennock JM, Doyle FH, Bydder GM (1982) Enhancement of relaxation rate with paramagnetic contrast agents in NMR imaging. J Comput Assist Tomogr 6: 1PubMedGoogle Scholar
  4. 4.
    Hahn PF, Stark DD, Saini S, Lewis JM, Wittenberg J, Ferrucci JT (1987) Ferrite particles for bowel contrast in MR imaging: design issues and feasibility studies. Radiology 164: 37PubMedGoogle Scholar
  5. 5.
    Weinreb JC, Maravilla KR, Redman HC, Nunnally R (1984) Improved MR imaging of the upper abdomen with glucagon and gas. J Comput Assist Tomogr 8: 835PubMedGoogle Scholar
  6. 6.
    Runge VM, Clanton JA, Lukehart CM, Partain CL, James AE (1983) Paramagnetic agents for contrast-enhanced NMR imaging: a review. AJR 141: 1209PubMedGoogle Scholar
  7. 7.
    Cory DA, Schwartzentruber J, Mock BH (1987) Ingested manganese chloride as a contrast agent for magnetic resonance imaging. Magn Reson Imaging 5: 65PubMedGoogle Scholar
  8. 8.
    George DE, Lebenthal E (1981) Human breast milk in comparison to cow's milk, In: Textbook of gastroenterology and nutrition in infancy, Vol 1. Raven Press, New York, pp 296–297Google Scholar
  9. 9.
    Ross Laboratories Product Handbook (1987) 48Google Scholar
  10. 10.
    Abramowicz M (1978) Oral iron. Med Lett Drugs Ther 20: 45PubMedGoogle Scholar
  11. 11.
    Kaufman RA (1983) Liver-spleen computed tomography: a method tailored for infants and children. J Comput Assist Tomogr 7: 45Google Scholar

Copyright information

© Springer-Verlag 1989

Authors and Affiliations

  • G. S. BissetIII
    • 1
    • 2
  1. 1.Department of Radiology and PediatricsUniversity of Cincinnati College of MedicineCincinnatiUSA
  2. 2.Department of RadiologyChildren's Hospital Medical CenterCincinnatiUSA

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