European Journal of Pediatrics

, Volume 149, Issue 6, pp 441–442 | Cite as

Efficacy of cyclosporin A for idiopathic pulmonary fibrosis

  • M. Fukazawa
  • M. Kawano
  • S. Hisano
  • K. Ueda
  • K. Matsuba


In an 11-year-old girl with severe dyspnoea and cyanosis, idiopathic pulmonary fibrosis (IPF) was diagnosed. The PaO2 of blood could be maintained between 50 mm Hg and 70 mm Hg with a high dose pulse corticosteroid therapy, although this dose could not be reduced. Azathioprine in addition to prednisolone provoked deterioration. Twelve weeks after admission, cyclosporin A (Cs A), a known immunosuppressant, was started together with prednisolone. The PaO2 reverted to normal within 1 month and prednisolone could be tapered off within 6 months. Two years after admission, the patient is free of symptoms on continuous Cs A therapy. This case seems to be the first case successfully treated with Cs A.

Key words

Idiopathic pulmonary fibrosis Cyclosporin A Corticosteroid 


Cs A

cyclosporin A


forced expiratory volume in 1 s


forced vital capacity


idiopathic pulmonary fibrosis


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Copyright information

© Springer-Verlag 1990

Authors and Affiliations

  • M. Fukazawa
    • 1
  • M. Kawano
    • 1
  • S. Hisano
    • 1
  • K. Ueda
    • 1
  • K. Matsuba
    • 2
  1. 1.Department of PaediatricsFukuoka 812Japan
  2. 2.Research Institute for Diseases of the Chest, Faculty of MedicineKyushu UniversityFukuoka 812Japan

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