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Antagonism of catecholamine inhibition of insulin secretion by methysergide

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Zusammenfassung

Isoliertes Maus-, Hamster- und Kaninchenpankreas wurde in einer physiologischen Pufferlösung mit 3,0 mg/ml Glukose inkubiert. Dopamin ruft eine erhebliche Verringerung der radioimmunologisch reagierenden Insulinsekretion hervor. Die durch Dopamin ausgelöste Hemmung lässt sich teilweise oder vollständig durch den Serotoninantagonisten 1-Methyl-d-lysergsäure butanolamid (Deseril) aufheben.

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Authors and Affiliations

  1. Division of Endocrinology, Department of Medicine, Duke University Medical Center, Box 2963, 27710, Durham, North Carolina, USA

    J. M. Feldman & H. E. Lebovitz

  2. Durhams Veterans Administration Hospital, 27710, Durham, North Carolina, USA

    J. M. Feldman & H. E. Lebovitz

Authors
  1. J. M. Feldman
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  2. H. E. Lebovitz
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Additional information

Supported by grants from the National Institute of Arthritis and Metabolic Diseases of the National Institutes of Health No. AM 01324, No. 5 T1 AM 5074 and No. K3 AM 17,954 and a Clinical Investigatorship from the Veterans Administration (JMF).

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Feldman, J.M., Lebovitz, H.E. Antagonism of catecholamine inhibition of insulin secretion by methysergide. Experientia 28, 433–434 (1972). https://doi.org/10.1007/BF02008324

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