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A note of the dual effect of prostaglandin E1 on the responses of the guinea-pig vas deferens to nerve stimulation

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Résumé

La prostaglandine E1 diminue les potentiels de jonction excitateurs du muscle lisse du vas deferens de cobaye en réponse à une stimulation nerveuse, mais provoque aussi une dépolarisation modérée de ce tissu. L'effet inhibiteur de la drogue sur la réponse motrice de cet organe à une stimulation nerveuse est attribué à la 1e de ces actions. L'effet stimulant sur la réponse motrice parfois constaté, est attribué à la seconde action.

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Author notes

  1. N. O. Sjöstrand

    Present address: Department of Physiology, Karolinska Institutet, S 104 01, Stockholm 60, Sweden

Authors and Affiliations

  1. Department of Pharmacology, University of Oxford, Oxford, England

    N. O. Sjöstrand

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  1. N. O. Sjöstrand
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Additional information

The generous hospitality of ProfessorEdith Bülbring F. R. S. is gratefully acknowledged. The investigation was supported by a grant to ProfessorBülbring from the Medical Research Council.

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Sjöstrand, N.O. A note of the dual effect of prostaglandin E1 on the responses of the guinea-pig vas deferens to nerve stimulation. Experientia 28, 431–432 (1972). https://doi.org/10.1007/BF02008323

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