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An urinary metabolite of bromazepam

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Zusammenfassung

Es wird über Versuche zur Isolierung von Metaboliten im Harn des Kaninchens und des Hundes nach einmaliger oraler Gabe von Bromazepam in hohen Dosen berichtet. Die Ergebnisse der Elementaranalyse und des UV-, IR-, NMR- und Massenspektren deuten darauf, dass es sich um das 3-Hydroxy-Derivat des 2-Amino-5-brombenzolypyridin handelt.

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References

  1. Bromazepam (Ro 5-3350) is synthesized byR. Iran Fryer, R. A. Schmidt andL. H. Sternbach, Department of Chemical Research, Hoffmann-La Roche, Inc., Nutley, N. J., USA (J. Pharm. Sci.),53, 264, 1964).

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Authors and Affiliations

  1. Department of Legal Medicine, Gifu University School of Medicine, Tsukasa-Machi 40, Gifu, Japan

    H. Sawada

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  1. H. Sawada
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Acknowledgment. The author is grateful to Dr.M. Fukumoto, Nippon Roche Research Center, Tokyo (Japan) for the gift of broamzepam. Thanks are also due to Prof.M. Hori and Prof.W. Sadée for interpretation of the IR-, NMR-, and mass-spectra.

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Sawada, H. An urinary metabolite of bromazepam. Experientia 28, 393–394 (1972). https://doi.org/10.1007/BF02008295

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  • DOI: https://doi.org/10.1007/BF02008295

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