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Reaction of DNA with phosphoric acid esters: Gasoline additive and insecticides

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Résumé

L'addition de phosphate triméthyl, “dichlorvos” (0, 0-dimethyl-2,2, dichlorovinyl phosphate) et du “diptérex” (0,0-dimethyl-2,2,2-trichloro-1-hydroxyethyl phosphonate) à du DNA provoque la dégradation de cette macromolécule. La réaction semble être due à une alkylation du résidu de guanine du DNA. Ces observations peuvent fournir une explication chimique aux effets biologiques de ces substances.

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References

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  6. Trimethyl phosphate was purchased from Aldrich Chemical Co., Inc., Milwaukee, Wis. Dipterex (Dylox) was received from Chemagro Corp., Kansas City, Mo., and dichlorvos (DDVP, Vapona) from Shell Chemical Co., San Ramon, Calif.

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  8. This investigation was supported by a grant from the Damon Runyon Memorial Fund for Cancer Research and by the Annie R. Masch Memorial Grant for Cancer Research from the American Cancer Society. One of the authors (H. S. R.) is a Research Career Development Awardee of the U.S. Public Health Service No. 2-K3-GM-29, 024.

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Authors and Affiliations

  1. Department of Microbiology, College of Physicians and Surgeons, Columbia University, 10032, New York, New York, USA

    H. S. Rosenkranz & S. Rosenkranz

Authors
  1. H. S. Rosenkranz
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  2. S. Rosenkranz
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Rosenkranz, H.S., Rosenkranz, S. Reaction of DNA with phosphoric acid esters: Gasoline additive and insecticides. Experientia 28, 386–387 (1972). https://doi.org/10.1007/BF02008290

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  • DOI: https://doi.org/10.1007/BF02008290

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