Calcified Tissue Research

, Volume 16, Issue 1, pp 201–207 | Cite as

Inorganic pyrophosphatase in mineralizing hamster molars

IV. Modification of the inhibition of EDTA, diphosphonates and L-ascorbic acid by Zn2+ and Co2+
  • J. H. M. Wöltgens
Original Papers

Abstract

Inorganic pyrophosphatase contains both Zn2+ and Co2+ in the active center. The highest activity of the enzyme was obtained in the Zn2+ form. EDTA, diphosphonates and L-ascorbic acid are able to inhibit PPi-ase by complexing Zn2+ and Co2+.

Key words

Teeth Pyrophosphatase Diphosphonates L-ascorbic acid 

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Copyright information

© Springer-Verlag 1974

Authors and Affiliations

  • J. H. M. Wöltgens
    • 1
  1. 1.Laboratory of Preventive Dentistry, College of MedicineVrije UniversiteitAmsterdamThe Netherlands

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