The effect of thyroid hormone on calcium-induced nephrocalcinosis in the jird (Meriones unguiculatus)
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Meriones unguiculatus (jirds or ‘gerbils’) were rendered hypo- or hyperthyroid by the addition of carbimazole or liothyronine to their diet, and in each of these states were found to be highly susceptible to the nephrotoxic effects of calcium gluconate. Histological studies showed that the pattern of induced nephrocalcinosis was the same in the hypo-, hyper- and eu-thyroid animals and was in the form of calcium deposits both within the cells of the proximal and distal convoluted tubules and in the basement membranes around such tubules.
In view of these findings analysis of thyroid function should perhaps be incorporated into the list of diagnostic procedures used in the investigation of patients with nephrocalcinosis and nephrolithiasis.
Key wordsHypothyroidism Hyperthyroidism Nephrocalcinosis Calcium
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