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Mutagenicity and toxicity of chloroethylene oxide and chloroacetaldehyde

Experientia volume 41, pages 676–677 (1985)Cite this article

Summary

Exposure of severaltrp-auxotrophicEscherichia coli strains, carrying base0pair substitutions, to chloroethylene oxide or chloroacetaldehyde (two metabolites of vinyl chloride) increased the mutation frequency to tryptophan prototrophy. Strong cytotoxic and mutagenic effects were observed with 2.5 mM chloroethylene oxide, while a higher concentration of chloroacetaldehyde (100 mM) exhibited a mutagenic effect which was 400 times lower.

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Author information

Author notes

  1. M. -H. Perrard

    Present address: INSERM U. 162, Hôpital Debrousse, 29, rue Sœur-Bouvier, F-69322, Lyon Cedex 05, France

Affiliations

  1. Laboratoire de Biochimie Microbienne, Université Claude-Bernard Lyon I, 43 boulevard du 11-Novembre 1918, F-69622, Villeurbanne Cedex, (France)

    M. -H. Perrard

  2. Unit of Chemical Carcinogenesis, International Agency for Research on Cancer, F-69008, Lyon, (France)

    M. -H. Perrard

Authors
  1. M. -H. Perrard
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Additional information

I am grateful to Prof. G. Michel, Laboratoire de Biochimie Microbienne, and to Dr H. Bartsch, International Agency for Research on Cancer, for the support of this work. I wish to thank Dr F. Besson-Simien and Dr A. Barbin for their collaboration.

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Perrard, M.H. Mutagenicity and toxicity of chloroethylene oxide and chloroacetaldehyde. Experientia 41, 676–677 (1985). https://doi.org/10.1007/BF02007715

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  • DOI: https://doi.org/10.1007/BF02007715

Key words

  • Chloroethylene oxide
  • chloroacetaldehyde
  • mutagenicity
  • toxicity,Escherichia coli