, Volume 41, Issue 5, pp 671–673 | Cite as

The potency of heparin-like activity of glycosaminoglycans released by human endothelial cells in culture

  • K. Shimada
  • I. Kusumoto
  • T. Ozawa
Short Communications Cellular and Molecular Biology, Immunology


Glycosaminoglycans isolated from culture medium conditioned by human endothelial cells showed heparin-like antithrombin III cofactor activity measured by Xa inhibition. Their activity was relatively weak, 0.1% of the potency of heparin, but was approximately 5-fold more potent than that of glycosaminoglycans derived from vascular smooth muscle cells.

Key words

Endothelial cells glycosaminoglycan heparin, smooth muscle cells 


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Copyright information

© Birkhäuser Verlag 1985

Authors and Affiliations

  • K. Shimada
    • 1
  • I. Kusumoto
    • 1
  • T. Ozawa
    • 1
  1. 1.Department of Medicine and GeriatricsKochi Medical SchoolKochi(Japan)

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