The potency of heparin-like activity of glycosaminoglycans released by human endothelial cells in culture
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Glycosaminoglycans isolated from culture medium conditioned by human endothelial cells showed heparin-like antithrombin III cofactor activity measured by Xa inhibition. Their activity was relatively weak, 0.1% of the potency of heparin, but was approximately 5-fold more potent than that of glycosaminoglycans derived from vascular smooth muscle cells.
Key wordsEndothelial cells glycosaminoglycan heparin, smooth muscle cells
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