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Experientia

, Volume 41, Issue 5, pp 666–667 | Cite as

The effect of cyclic AMP on Na+ and K+ transport systems in mouse macrophages

  • J. Diez
  • P. Braquet
  • R. Verna
  • C. Nazaret
  • R. P. Garay
Short Communications Cellular and Molecular Biology, Immunology

Summary

Exogenous cyclic AMP (cAMP) inhibits the Na+, K+-cotransport system and stimulates the Na+, K+-pump and Na+, Ca2+ exchange in mouse macrophages. These effects are enhanced by inhibition of phosphodiesterase with methylisobutylxanthine (MIX). MIX alone showed little or no effect. A similar response was observed after stimulation of endogenous production of cAMP by isoproterenol.

Key words

Na+ K+ transport macrophages cyclic AMP mouse 

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Copyright information

© Birkhäuser Verlag 1985

Authors and Affiliations

  • J. Diez
    • 1
  • P. Braquet
    • 1
  • R. Verna
    • 1
  • C. Nazaret
    • 1
  • R. P. Garay
    • 1
  1. 1.INSERM U7/CNRS LA 318Hopital NeckerParis(France)

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