, Volume 41, Issue 1, pp 125–127 | Cite as

Intraocular 6-hydroxydopamine prevents the persistent estrus induced by continuous light

  • K. Shimizu
  • M. Hokano
Short Communications Neurology, Behavior


Following the intraocular injection of 6-hydroxydopamine, which can destroy the retinal dopaminergic neurons, female rats showed a normal estrous cycle in LD 12∶12 but not a persistent estrus in continuous light.

Key words

6-Hydroxydopamine intraocular administration continuous light persistent estrus female rat 


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 1.
    Rusak, B., and Zucker, I., Physiol. Rev.59 (1979) 449.Google Scholar
  2. 2.
    Underwood, H., and Groos, G., Experientia38 (1982) 1013.PubMedGoogle Scholar
  3. 3.
    Kato, S., Nakamura, T., and Negishi, K., J. comp. Neurol.191 (1980) 227.Google Scholar
  4. 4.
    Ehinger, B., and Flack, B., Albrecht v. Graefes Arch. Ophthal.178 (1969) 295.Google Scholar
  5. 5.
    Dowling, J. E., and Ehinger, B., J. comp. Neurol.180 (1978) 203.PubMedGoogle Scholar
  6. 6.
    Holmgren, I., Invest. Ophthalmol. Vis. Sci.22 (1982) 8.PubMedGoogle Scholar
  7. 7.
    Kramer, S. G., Invest. Ophthalmol.10 (1971) 438.PubMedGoogle Scholar
  8. 8.
    Marler, P., and Hamilton, W. J., III, in: Mechanism of animal behavior, p. 25. Wiley and Toppan, Tokyo 1966.Google Scholar
  9. 9.
    Hoffmann, J. C., in: Handbook of physiology, vol. 2, sec. 7, p. 57. Ed. R. O. Greep. Am. physiol. Soc., Washington D.C. 1973.Google Scholar
  10. 10.
    McCromack, C. E., and Sridaran, R., J. Endocr.76 (1978) 135.PubMedGoogle Scholar
  11. 11.
    Lawton, I. E., and Schwartz, N. B., Endocrinology81 (1969) 497.Google Scholar
  12. 12.
    Ehinger, B., Acta physiol. scand. suppl.452 (1977) 47.Google Scholar
  13. 13.
    Dowling, J. E., Ehinger, B., and Florén, I., J. comp. Neurol.192 (1980) 665.PubMedGoogle Scholar
  14. 14.
    Shimizu, K., Furuya, T., Takeo, Y., Shirama, K., and Maekawa, K., Experientia39 (1983) 104.PubMedGoogle Scholar
  15. 15.
    Invone, P. M., Galli, C. L., Garrison-Gund, C. K., and Neff, N. H., Science202 (1978) 901.Google Scholar
  16. 16.
    Frucht, Y., Vidauri, J., and Melamed, E., Brain Res.249 (1982) 153.PubMedGoogle Scholar
  17. 17.
    Wirz-Justice, A., Da Prada, M., and Remé, C., Neurosci. Lett.45 (1984) 21.PubMedGoogle Scholar

Copyright information

© Birkhäuser Verlag 1985

Authors and Affiliations

  • K. Shimizu
    • 1
  • M. Hokano
    • 1
  1. 1.Department of AnatomyTokyo Medical CollegeTokyoJapan

Personalised recommendations