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Bicuculline and picrotoxin block γ-aminobutryic acid-gated Cl− conductance by different mechanisms

Experientia volume 41, pages 70–71 (1985)Cite this article

Summary

Using isolated, internally perfused bullfrog dorsal root ganglion cells we have studied the dose-response curves for γ-aminobutyric acid (GABA) in the presence of internally or externally applied GABA antagonists. With external application of antagonists the inhibition of the GABA current by bicuculline was competitive and that by picrotoxin was noncompetitive. Picrotoxin but not bicuculline blocked when internally perfused.

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Affiliations

  1. Department of Physiology, Faculty of Medicine, Kyushu University 60, 812, Fukuoka, Japan

    N. Akaike, K. Hattori, Y. Oomura & D. O. Carpenter

  2. Center for Laboratories and Research, New York State Department of Health, 12201, Albany, New York, USA

    N. Akaike, K. Hattori, Y. Oomura & D. O. Carpenter

Authors
  1. N. Akaike
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  2. K. Hattori
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  3. Y. Oomura
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  4. D. O. Carpenter
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To whom reprint requests should be addressed.

Acknowledgments. We thank Drs S. Minakami and S. Yasui for helpful discussions and comments.

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Akaike, N., Hattori, K., Oomura, Y. et al. Bicuculline and picrotoxin block γ-aminobutryic acid-gated Cl− conductance by different mechanisms. Experientia 41, 70–71 (1985). https://doi.org/10.1007/BF02005880

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  • DOI: https://doi.org/10.1007/BF02005880

Key words

  • γ-Aminobutyric acid
  • bicuculline
  • picrotoxin
  • internal perfusion
  • competition blockade
  • channel blockade
  • frog dorsal root ganglion