Summary
The influences of presure and volume changes in one ventricle on the other ventricle may be determined from the relative compliances of the ventricular free walls and the interventricular septum. If this is correct, then disease states which alter regional compliances should influence the diastolic mechanical coupling between the ventricles. To examine this hypothesis, the hearts of 15 canine dogs were removed and placed in cool cardioplegic solution. Balloons were inserted into each ventricle and the right and left ventricular pressure (ΔPr, ΔPl) and volume (ΔVr, ΔVl) changes caused by changing the pressure and volume of the other ventricle were recorded. Acute changes in right ventricular free wall (N=5), septal (N=5), and left ventricular free wall (N=5) compliances were induced by glutaraldehyde injections. After injecting glutaraldehyde into the right coronary artery, ΔPl/ΔVr, ΔVl/ΔVr, ΔPr/ΔPl, and ΔPr/ΔVl increased significantly (P<0.05). After septal artery injection, pressure and volume transfer between the ventricles was significantly depressed. After left coronary artery injection, ΔPl/ΔPr, ΔPl/ΔVr, ΔPr/ΔVl, and ΔVr/ΔVl increased significantly (P<0.05). Thus, selective alterations in the mechanical coupling between the ventricles occurred following changes in right ventricular, septal, and left ventricular free wall compliances. Such changes may be important in diseases which primarily affect one side of the heart.
Similar content being viewed by others
References
Blair E (1961) Anatomy of the ventricular coronary arteries in the dog. Circ Res 9:333–341
Brilla C, Kissling G, Jacob R (1987) Significance of right ventricular filling for left ventricular enddiastolic pressure-volume relationship under acute hypoxia in the dog. Basic Res Cardiol 82:109–122
Brinker JA, Weiss JL, Lappe DL, Rabson JL, Summer WR, Permutt S, Weisfeldt ML (1980) Leftward septal displacement during right ventricular loading in man. Circ 61:626–633
Elzinga G, van Grondelle R, Westerhof N, van den Bos GC (1974) Ventricular interference. Am J Physiol 2266:941–947
Fujii J, Yazaki Y, Sawada H, Aizawa T, Watanabe H, Kato K (1985) Noninvasive assessment of left and right ventricular filling in myocardial infaction with a two-dimensional Doppler echocardiographic method. J Am Coll Cardiol 5:155–1160
Hassler GB, Rodigas PC, Spotnitz HM (1982) The absence of temperature effects on end-diastolic pressure-volume relations in the canine left ventricle determined by two-dimensional echocardiography. J Thorac Cardiovasc Surg 83:878–890
Janicki JS, Weber KT (1980) The pericardium and ventricular interaction, distensibility and function. Am J Physiol 238:H494-H503, 1980
Little WC, Badke FR, O'Rourke RA (1984) Effect of right ventricular pressure on the end-diastolic left ventricular pressure-volume relationship before and after chronic right ventricular pressure overload. Circ Res 54:719–730
Rosenkranz ER, Buckberg GD (1983) Myocardial protection during surgical coronary reperfusion. J Am Coll Cardiol 1:1235–1246
Santamore WP, Shaffer T, Hughes D (1986) A theoretical and experimental model of ventricular interdependence. Basic Res Cardiol 81:529–537
Santamore WP, Bartlett R, Van Buren SJ, Dowd MK, Kutcher MA (1986) Ventricular coupling in constrictive pericarditis. Circulation 74:547–602
Santamore WP, Lynch PR, Meier GM, Bove AA, Heckman JL (1976) Myocardial interaction between the ventricles. J Appl Physiol 41:362–368
Shabetai R, Mangiardei L, Bhargava V, Ross J Jr, Higgins CB (1979) The pericardium and cardiac function. Prog Cardiovasc Dis 22:102–134
Steel, Torrie (1980) Principles and Procedures of Statistics. McGraw-Hill, New York, Chapt 7:137–167
Sunagawa K, Maughan WL, Weisfeldt ML, Sagawa K (1981) Effect of systolic trans-septal pressure on septal elastance and ventricular cross talk. (Abst) Circulation 64 (Suppl IV):180
Ullrich KJ, Riecker G, Kramer KL (1954) Das Druckvolumendiagramm des Warmblüterherzens. Isometrische Gleichgewichtskurven. Pflügers Arch 259:481–498
Author information
Authors and Affiliations
Additional information
This study was supported in part by NIH Grant No. HL 36068 by a grant from the American Heart Association, New Jersey Chapter.
Rights and permissions
About this article
Cite this article
Santamore, W.P., Constantinescu, M., Minczak, B.M. et al. Contribution of each ventricular wall to ventricular interdependence. Basic Res Cardiol 83, 424–430 (1988). https://doi.org/10.1007/BF02005828
Received:
Issue Date:
DOI: https://doi.org/10.1007/BF02005828