Suppression of monosodium urate crystal-induced inflammation by black currant seed oil

Abstract

The subcutaneous air pouch formed in Sprague-Dawley rats was used to study the effect of diets enriched in black currant seed oil (BCSO) on acute inflammation induced by monosodium urate crystals. The BCSO enriched diet suppressed significantly both the cellular and fluid phases of inflammation (polymorphonuclear leucocyte and exudate accumulation). In contrast, administration of normal chow or of a diet enriched in safflower oil (polyunsaturated fatty acid control) did not influence monosodium urate crystal-induced inflammation in this model. The findings indicate that a diet which provides both n-6 (gammalinolenic acid) and n-3 (alphalinolenic acid) fatty acids as substrates alternative to arachidonatic acid for oxidative metabolism, modifies monosodium urate crystal-induced acute inflammation.

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References

  1. [1]

    D. Vance,Metabolism of fatty acids and triacylglycerols. In Biochemistry. (Ed. G. Zubray) Addison-Wesley, Reading, MA, 1983.

    Google Scholar 

  2. [2]

    A. Raz, M. S. Minkes and P. Needleman,Endoperoxides and thromboxanes: Structural determinants for platelet aggregation and vasoconstriction. Biochim, Biophys. Acta488, 305–311 (1977).

    Google Scholar 

  3. [3]

    T. H. Lee, R. L. Hoover, J. D. Williams, R. I. Sperling, J. Ravelese, B. W. Spur, D. R. Robinson, E. J. Corey, R. A. Lewis and K. E. Austen,Effect of dietary enrichment with eicosapentaenoic and docosahexaenoic acids on in vitro neutrophil and monocyte leukotriene generation and neutrophil function. New Engl. J. Med.312, 1217–1221 (1985).

    PubMed  Google Scholar 

  4. [4]

    P. B. A. Kernoff, A. L. Willis, K. J. Stone, J. A. Davies and G. P. McNichol,Antithrombotic potential of dihomo-gamma-linolenic acid in man. Br. Med. J.2, 1441–1444 (1977).

    PubMed  Google Scholar 

  5. [5]

    S. Hammarstrom,Conversion of dihomogammalinolenic acid to an isomer of leukotriene C3 oxygenated at C8. J. Biol. Chem.256, 7712–7715 (1981).

    PubMed  Google Scholar 

  6. [6]

    J. M. Kremer, W. Jubiz, A. Michalek, R. Rynes, L. Bartholomew, J. Bigaouette, M. Timchalk, D. Beeler and L. Lininger,Fish oil fatty acid supplementation in active rheumatoid arthritis. Ann. Intern. Med.106, 497–503 (1987).

    PubMed  Google Scholar 

  7. [7]

    J. J. F. Belch, D. Ansell, K. R. Madho, A. O'Dowd and R. D. Sturrock,The effects of altering dietary essential fatty acids on requirements for nonsteroidal antiinflammatory drugs in patients with rheumatoid arthritis: a double-blind placebo controlled study. Ann. Rheum. Dis.47, 96–104 (1988).

    PubMed  Google Scholar 

  8. [8]

    J. D. Prickett, D. R. Robinson and A. D. Steinberg,Effects of dietary enrichment with eicosapentaenoic acid upon autoimmune nephritis in female NZB×NZW/F 1 mice. Arth. Rheum.26, 133–139 (1983).

    Google Scholar 

  9. [9]

    S. L. Kunkel, H. Ogawa, P. A. Ward and R. B. Zurier,Suppression of chronic inflammation by evening primrose oil. Prog. Lipid. Res.20, 885–887 (1981).

    Article  PubMed  Google Scholar 

  10. [10]

    G. A. Tate, B. F. Mandell, R. A. Karmali, M. Laposata, D. G. Baker, H. R. Schumacher and R. B. Zurier,Suppression of monosodium urate crystal-induced acute inflammation by diets enriched with gammalinolenic acid and eicosapentaenoic acid. Arth. Rheum.31, 1543–1551 (1988).

    Google Scholar 

  11. [11]

    B. A. Nassar, Y. S. Huang, M. S. Manku, U. N. Das, N. Mors and D. F. Horrobin,The influence of dietary manipulation with n-3 and n-6 fatty acids on liver and plasma phospholipid fatty acids in rats. Lipids21, 652–656 (1986).

    PubMed  Google Scholar 

  12. [12]

    H. Traitler, H. J. Wille and A. Studer,Fractionation of black currant seed oil. JAOCS65, 755–760 (1988).

    Google Scholar 

  13. [13]

    J. W. Edwards, A. D. Sedgwick and D. D. Willoughby,The formation of a structure with the features of synovial lining by subcutaneous injections of air; an in vivo tissue culture system. J. Pathol.134, 147–153 (1981).

    Article  PubMed  Google Scholar 

  14. [14]

    D. J. McCarty and Faires,A comparison of the duration of local antiinflammatory effects of several adreno-cortical esters: a bioassay technique. Curr. Ther. Res.5, 284–290 (1963).

    PubMed  Google Scholar 

  15. [15]

    S. Endres, R. Ghorbani, V. E. Kelley, G. Georgilisk, G. Lonnemann, J. W. M. van der Meer, J. G. Cannon, T. S. Rogers, M. S. Klempner, P. C. Weber, P. C. Weber, E. J. Schaefer, S. M. Wolf and C. A. Dinarello,The effect of dietary supplementation with n-3 polyunsaturated fatty acids on the synthesis of interleukin-1 and tumor necrossis factor by mononuclear cells. New Engl. J. Med.320, 265–271 (1989).

    PubMed  Google Scholar 

  16. [16]

    J. Seelig and N. Waespe-Sarcevic,Molecular order in cis and trans unsaturated phospholipid bilayers. Biochemistry17, 3310–3315 (1978).

    Article  PubMed  Google Scholar 

  17. [17]

    E. J. McMurchie,Dietary lipids and the regulation of membrane fluidity and function. In:Physiological Regulation of Membrane Fluidity. (Eds. R. C. Aloid, C. C. Curtain and L. M. Gordon pp. 189–237, Alan R. Liss, New York, 1988.

    Google Scholar 

  18. [18]

    D. Santoli and R. B. Zurier,Prostaglandin E (PGE) precursor fatty acids inhibit human IL-2 production by a PGE-independent mechanism. J. Immunol.143, 1303–1309 (1989).

    PubMed  Google Scholar 

  19. [19]

    D. Santoli, P. D. Phillips, T. L. Colt and R. B. Zurier,Suppression of interleukin-2 dependent human T cell growth by E-series prostaglandins (PGE) and their precursor fatty acids: Evidence for a PGE-independent mechanism of inhibition by the fatty acids. J Clin Invest85, 424–432 (1990).

    PubMed  Google Scholar 

  20. [20]

    A. L. Willis,Nutritional and pharmacological factors in eicosanoid biology. Nutr. Rev.39, 289–300 (1981).

    PubMed  Google Scholar 

  21. [21]

    S. Pullman-Mooar, M. Laposata, D. Lem, R. T. Holman, L. J. Leventhal, D. DeMarco and R. B. Zurier,Alteration of the cellular fatty acid profile and the production of eicosanoids in human monocytes by gamalinolenic acid. Arth. Rheum.33, 1526–1533 (1990).

    Google Scholar 

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Tate, G.A., Zurier, R.B. Suppression of monosodium urate crystal-induced inflammation by black currant seed oil. Agents and Actions 43, 35–38 (1994). https://doi.org/10.1007/BF02005761

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Key words

  • Gammalinolenate
  • Inflammation
  • Black currant oil