The subcutaneous air pouch formed in Sprague-Dawley rats was used to study the effect of diets enriched in black currant seed oil (BCSO) on acute inflammation induced by monosodium urate crystals. The BCSO enriched diet suppressed significantly both the cellular and fluid phases of inflammation (polymorphonuclear leucocyte and exudate accumulation). In contrast, administration of normal chow or of a diet enriched in safflower oil (polyunsaturated fatty acid control) did not influence monosodium urate crystal-induced inflammation in this model. The findings indicate that a diet which provides both n-6 (gammalinolenic acid) and n-3 (alphalinolenic acid) fatty acids as substrates alternative to arachidonatic acid for oxidative metabolism, modifies monosodium urate crystal-induced acute inflammation.
This is a preview of subscription content, access via your institution.
Buy single article
Instant access to the full article PDF.
Tax calculation will be finalised during checkout.
Subscribe to journal
Immediate online access to all issues from 2019. Subscription will auto renew annually.
Tax calculation will be finalised during checkout.
D. Vance,Metabolism of fatty acids and triacylglycerols. In Biochemistry. (Ed. G. Zubray) Addison-Wesley, Reading, MA, 1983.
A. Raz, M. S. Minkes and P. Needleman,Endoperoxides and thromboxanes: Structural determinants for platelet aggregation and vasoconstriction. Biochim, Biophys. Acta488, 305–311 (1977).
T. H. Lee, R. L. Hoover, J. D. Williams, R. I. Sperling, J. Ravelese, B. W. Spur, D. R. Robinson, E. J. Corey, R. A. Lewis and K. E. Austen,Effect of dietary enrichment with eicosapentaenoic and docosahexaenoic acids on in vitro neutrophil and monocyte leukotriene generation and neutrophil function. New Engl. J. Med.312, 1217–1221 (1985).
P. B. A. Kernoff, A. L. Willis, K. J. Stone, J. A. Davies and G. P. McNichol,Antithrombotic potential of dihomo-gamma-linolenic acid in man. Br. Med. J.2, 1441–1444 (1977).
S. Hammarstrom,Conversion of dihomogammalinolenic acid to an isomer of leukotriene C3 oxygenated at C8. J. Biol. Chem.256, 7712–7715 (1981).
J. M. Kremer, W. Jubiz, A. Michalek, R. Rynes, L. Bartholomew, J. Bigaouette, M. Timchalk, D. Beeler and L. Lininger,Fish oil fatty acid supplementation in active rheumatoid arthritis. Ann. Intern. Med.106, 497–503 (1987).
J. J. F. Belch, D. Ansell, K. R. Madho, A. O'Dowd and R. D. Sturrock,The effects of altering dietary essential fatty acids on requirements for nonsteroidal antiinflammatory drugs in patients with rheumatoid arthritis: a double-blind placebo controlled study. Ann. Rheum. Dis.47, 96–104 (1988).
J. D. Prickett, D. R. Robinson and A. D. Steinberg,Effects of dietary enrichment with eicosapentaenoic acid upon autoimmune nephritis in female NZB×NZW/F 1 mice. Arth. Rheum.26, 133–139 (1983).
S. L. Kunkel, H. Ogawa, P. A. Ward and R. B. Zurier,Suppression of chronic inflammation by evening primrose oil. Prog. Lipid. Res.20, 885–887 (1981).
G. A. Tate, B. F. Mandell, R. A. Karmali, M. Laposata, D. G. Baker, H. R. Schumacher and R. B. Zurier,Suppression of monosodium urate crystal-induced acute inflammation by diets enriched with gammalinolenic acid and eicosapentaenoic acid. Arth. Rheum.31, 1543–1551 (1988).
B. A. Nassar, Y. S. Huang, M. S. Manku, U. N. Das, N. Mors and D. F. Horrobin,The influence of dietary manipulation with n-3 and n-6 fatty acids on liver and plasma phospholipid fatty acids in rats. Lipids21, 652–656 (1986).
H. Traitler, H. J. Wille and A. Studer,Fractionation of black currant seed oil. JAOCS65, 755–760 (1988).
J. W. Edwards, A. D. Sedgwick and D. D. Willoughby,The formation of a structure with the features of synovial lining by subcutaneous injections of air; an in vivo tissue culture system. J. Pathol.134, 147–153 (1981).
D. J. McCarty and Faires,A comparison of the duration of local antiinflammatory effects of several adreno-cortical esters: a bioassay technique. Curr. Ther. Res.5, 284–290 (1963).
S. Endres, R. Ghorbani, V. E. Kelley, G. Georgilisk, G. Lonnemann, J. W. M. van der Meer, J. G. Cannon, T. S. Rogers, M. S. Klempner, P. C. Weber, P. C. Weber, E. J. Schaefer, S. M. Wolf and C. A. Dinarello,The effect of dietary supplementation with n-3 polyunsaturated fatty acids on the synthesis of interleukin-1 and tumor necrossis factor by mononuclear cells. New Engl. J. Med.320, 265–271 (1989).
J. Seelig and N. Waespe-Sarcevic,Molecular order in cis and trans unsaturated phospholipid bilayers. Biochemistry17, 3310–3315 (1978).
E. J. McMurchie,Dietary lipids and the regulation of membrane fluidity and function. In:Physiological Regulation of Membrane Fluidity. (Eds. R. C. Aloid, C. C. Curtain and L. M. Gordon pp. 189–237, Alan R. Liss, New York, 1988.
D. Santoli and R. B. Zurier,Prostaglandin E (PGE) precursor fatty acids inhibit human IL-2 production by a PGE-independent mechanism. J. Immunol.143, 1303–1309 (1989).
D. Santoli, P. D. Phillips, T. L. Colt and R. B. Zurier,Suppression of interleukin-2 dependent human T cell growth by E-series prostaglandins (PGE) and their precursor fatty acids: Evidence for a PGE-independent mechanism of inhibition by the fatty acids. J Clin Invest85, 424–432 (1990).
A. L. Willis,Nutritional and pharmacological factors in eicosanoid biology. Nutr. Rev.39, 289–300 (1981).
S. Pullman-Mooar, M. Laposata, D. Lem, R. T. Holman, L. J. Leventhal, D. DeMarco and R. B. Zurier,Alteration of the cellular fatty acid profile and the production of eicosanoids in human monocytes by gamalinolenic acid. Arth. Rheum.33, 1526–1533 (1990).
About this article
Cite this article
Tate, G.A., Zurier, R.B. Suppression of monosodium urate crystal-induced inflammation by black currant seed oil. Agents and Actions 43, 35–38 (1994). https://doi.org/10.1007/BF02005761
- Black currant oil