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The topically irritant substance: Essentials — bio-tests — predictions

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Abstract

The paper describes a method for judging the irritative potentialities of substances; proposes a scoring system with which the ‘ordinary’ risks of many of the abundant marketed products for washing, cleaning etc. may be prdicted,without biological testing; discusses pharmacodynamic and pharmacokinetic aspects of topical irritancy and points to the problems of extrapolating from animal experiments to man.

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Authors and Affiliations

  1. Department of Pharmacology (701), Biocentre, University of Basel, 4056, Basel, Switzerland

    K. Bucher, K. E. Bucher & D. Walz

Authors
  1. K. Bucher
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  2. K. E. Bucher
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  3. D. Walz
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Additional information

This work was encouraged and financially supported by the Swiss Federal Office of Health, Section Toxicology.

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Bucher, K., Bucher, K.E. & Walz, D. The topically irritant substance: Essentials — bio-tests — predictions. Agents and Actions 11, 515–519 (1981). https://doi.org/10.1007/BF02004715

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  • DOI: https://doi.org/10.1007/BF02004715

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