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Glia maturation factor influences recovery from injury in neonatal rat brains

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Summary

Newborn rats were injured with a puncture wound in one cerebral hemisphere. Experimental animals were treated with three i.p. injections of Glia Maturation Factor (GMF) at daily intervals starting from the time of injury, whereas control littermates were treated with equivalent amounts of bovine serum albumin. At 25 days old the size of the cerebral cortex at the plane of injury was measured on representative brain sections. In control rats the injured side was 18% smaller than the normal side whereas in GMF-treated animals the difference was only 1%. The results suggest a possible regulatory role of GMF in promoting tissue recovery from brain damage.

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Authors and Affiliations

  1. Veterans Administration Medical Center, University of Iowa College of Medicine, 52242, Iowa City, Iowa, USA

    R. Lim & J. F. Miller

  2. Department of Neurology, Division of Neurochemistry and Neurobiology, University of Iowa College of Medicine, 52242, Iowa City, Iowa, USA

    R. Lim & J. F. Miller

Authors
  1. R. Lim
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  2. J. F. Miller
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Additional information

Acknowledgments. This work was supported by the following research grants to Dr Lim: Veterans Administration Merit Review Award and Clinical Investigatorship Award, National Science Foundation grant No.BNS-8308341 and National Cancer Institute grant No. CA-31796. We thank Marjorie Strabala for preparing the histological sections and Dr Peter A. Lachenbruch and John Tsuang for statistical analysis.

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Lim, R., Miller, J.F. Glia maturation factor influences recovery from injury in neonatal rat brains. Experientia 41, 412–415 (1985). https://doi.org/10.1007/BF02004534

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