Summary
Digoxin was demonstrated inTetrahymena pyriformis by radioimmunoassay, at a concentration of 4.3 ng/100,000 cells. Pretreatment of the cells with digoxin or ouabain did not significantly alter the digoxin concentration of the progeny generations.
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Supported by the Scientific Research Council Ministry of Health, Hungary 16/1-04/432/Cs.
Csaba, G., Biol Rev.55 (1980) 47.
Csaba, G., Ontogeny and phylogeny of hormone receptors. Karger, Basel/New York 1981.
Janakivedi, D., Devey, J. C., and Kidder, W. C., J. biol. Chem.224 (1973) 132.
Kassis, S., and Kindler, S. H., Biochim. biophys. Acta391 (1975) 513.
Le Roith, D., Shiloach, J., Roth, J., and Lesniak, M. A., Proc. natl Acad. Sci. (USA)77 (1980) 6184.
Berelowitz, M., Le Roith, D., von Schenk, K. H., Newgard, C., Szabo, M., Frohman, L. A., Shiloach, J., and Roth, J., Endocrinology110 (1982) 1939.
Le Roith, D., Liotta, A. S., Roth, J., Shiloach, J., Lewis, M. E., Pert, C. B., and Krieger, D. T., Proc. natl Acad. Sci. USA79 (1982) 2086.
Le Roith, D., Shiloach, J., Berelowitz, M., Frohman, L. A., Liotta, A. S., Krieger, D. T., and Roth, J., Fedn Proc.42 (1983) 2602.
Schwabe, C., Le Roith, D., Thompson, R. P., Shiloach, J., and Roth, J., J. biol. Chem.258 (1983) 2778.
Darvas, Zs., Swydan, R., Csaba, G., László, V., and Nagy, S. U., Acta physiol. hung. (1985) in press.
Csaba, G., Németh, G., and Vargha, P., Z. Naturforsch.37 (1982) 1042.
Moe, G. K., and Farah, A. E., Cardiovascular drugs, in: The pharmacological basis of therepeutics, p. 677. Eds L. S. Goodman and A. Gilman. MacMillan, London/Toronto 1971.
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Csaba, G., Darvas, Z., Swydan, R. et al. Presence of digoxin detectable by radioimmunoassay in Tetrahymena. Experientia 41, 392–393 (1985). https://doi.org/10.1007/BF02004523
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DOI: https://doi.org/10.1007/BF02004523