, Volume 41, Issue 3, pp 379–382 | Cite as

Growth inhibitory, insecticidal and antifeedant effects of some antileukemic and cytotoxic quassinoids on two species of agricultural pests

  • J. A. Klocke
  • M. Arisawa
  • S. S. Handa
  • A. D. Kinghorn
  • G. A. Cordell
  • N. R. Farnsworth


Several quassinoids, obtained by isolation and derivatization fromSimaba multiflora andSoulamea soulameoides, were evaluated for growth inhibitory and insecticidal effects against the tobacco budworm (Heliothis virescens) and for antifeedant effects againstH. virescens and the fall armyworm (Spodoptera frugiperda). The relative activity of the quassinoids as insect growth inhibitors generally paralleled their known relative potency as antileukemic and cytotoxic agents.

Key Words

Quassinoids Heliothis virescens Spodoptera frugiperda growth inhibitory effects antifeedant effects antileukemic activity cytotoxic activity 


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Copyright information

© Birkhäuser Verlag 1995

Authors and Affiliations

  • J. A. Klocke
    • 1
    • 2
  • M. Arisawa
    • 1
    • 2
  • S. S. Handa
    • 1
    • 2
  • A. D. Kinghorn
    • 1
    • 2
  • G. A. Cordell
    • 1
    • 2
  • N. R. Farnsworth
    • 1
    • 2
  1. 1.Plant Resources InstituteUniversity Research ParkSalt Lake CityUSA
  2. 2.Program for Collaborative Research in the Pharmaceutical Sciences, College of Pharmacy, Health Sciences CenterUniversity of Illinois at ChicagoChicagoUSA

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