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Reduced collagen biosynthesis in oral mucosa of beige (Chediak-Higashi) mice

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Summary

Oral mucosa of beige (Chediak-Higashi) mice had decreased levels of collagen synthesis and prolyl hydroxylase activity compared with normal animals. No significant difference was observed in non-collagen protein synthesis between the two groups. These results suggest that decreased collagen biosynthesis in oral tissues may be partially involved in the increased incidence of periodontal disease in the Chediak-Higashi syndrome.

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Authors and Affiliations

  1. Department of Oral Pathology, Josai Dental University, 350-02, Sakado, Saitama, Japan

    H. Shikata, M. Hiramatsu, K. Ikeda, N. Utsumi, T. Asano & T. Shikata

  2. Department of Dental Pharmacology, Josai Dental University, 350-02, Sakado, Saitama, Japan

    H. Shikata, M. Hiramatsu, K. Ikeda, N. Utsumi, T. Asano & T. Shikata

  3. Department of Periodontology, Josai Dental University, 350-02, Sakado, Saitama, Japan

    H. Shikata, M. Hiramatsu, K. Ikeda, N. Utsumi, T. Asano & T. Shikata

  4. National Institute of Health, 141, Tokyo, Japan

    H. Shikata, M. Hiramatsu, K. Ikeda, N. Utsumi, T. Asano & T. Shikata

  5. Nihon University School of Medicine, 141, Tokyo, Japan

    H. Shikata, M. Hiramatsu, K. Ikeda, N. Utsumi, T. Asano & T. Shikata

Authors
  1. H. Shikata
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  2. M. Hiramatsu
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  3. K. Ikeda
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  4. N. Utsumi
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  5. T. Asano
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  6. T. Shikata
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Shikata, H., Hiramatsu, M., Ikeda, K. et al. Reduced collagen biosynthesis in oral mucosa of beige (Chediak-Higashi) mice. Experientia 41, 365–366 (1985). https://doi.org/10.1007/BF02004507

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  • DOI: https://doi.org/10.1007/BF02004507

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