Summary
Sodium deoxycholate (DOC), selected as a promoter of gastrointestinal absorption of heparin, was administered orally to rats, followed, at increasing intervals, by heparin. Maximal plasma clearing activity (PC) was obtained with a 60-min interval, though PC was still elicited after 24 h, suggesting that DOC acts on the gastrointestinal mucosa. Inhibition of blood coagulation was also observed after oral heparin. The suggestion that DOC increases heparin absorptions is supported by increased plasma levels of heparin. No signs of several gastrointestinal damage were seen.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
Pritchard, J., J. Pharm. Pharmac.16 (1964) 487.
Engel, R. H., and Riggi, S. J., Proc. Soc. exp. Biol. Med.130 (1969) 879.
Engel, R. H., and Riggi, S. J., J. pharm. Sci.58 (1969) 706.
Kidron, M., Eldor, A., Lichtenberg, D., Touitou, E., Ziv., E., and Bar-On, H., Thromb. Res.16 (1979) 833.
Guarini, S., and Ferrari, W., submitted for publication.
Guarini, S., Riv. Farmac. Ter.13 (1982) 293.
Tokunaga, Y., Muranishi, S., and Sezaki, H., J. pharm. Dyn.1 (1978) 28.
Ziv, E., Eldor, A., Kleinman, Y., Bar-On, H., and Kidron, M., Biochem. Pharmac.32 (1983) 773.
Gibaldi, M., and Feldman, S., J. pharm. Sci.59 (1970) 579.
Davis, W. W., Pfeiffer, R. R., and Quay, J. F., J. pharm. Sci.59 (1970) 960.
Withmore, D. A., Brookes, L. G., and Wheeler, K. P., J. Pharm. Pharmac.31 (1979) 277.
Grossman, M. I., J. Lab. clin. Med.43 (1954) 445.
Ferlito, S., Puleo, F., Carrà, G., La Spina, E., and Del Campo, F., G. Clin. Med.61 (1980) 221.
Gigante, D., and Raggio-Guarnaschelli A. E., Il laboratorio di analisi cliniche, p. 504. Abruzzini, Rome 1955.
Guarini, S., and Ferrari, W., Riv. Farmac. Ter.14 (1983) 11.
Touitou, E., Donbrow, M., and Rubinstein, A., J. Pharm. Pharmac.32 (1980) 108.
Nishihata, T., Rytting, J. H., Kamada, A., Higuchi, T., Routh, M., and Caldwell, L., J. Pharm. Pharmac.35 (1983) 148.
Nishihata, T., Rytting, J. H., and Higuchi, T., J. pharm. Sci.70 (1981) 71.
Yonezawa, M., Nihon Univ. J. Med.19 (1977) 125.
Nissim, J. A., Nature187 (1960) 305.
Nishioka, Y., and Kawamura, T., Yakuzaigaku (Japan)38 (1978) 67.
Teem, M. V., and Philips, S. F., Gastroenterology62 (1972) 261.
Yamasaki, Y., Shichiri, M., Kawamori, R., Morishima, T., Hakui, N., Yagi, T., and Abe, H., Can. J. Physiol. Pharmac.59 (1981) 1.
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Guarini, S., Ferrari, W. Sodium deoxycholate promotes the absorption of heparin administered orally, probably by acting on gastrointestinal mucosa, in rats. Experientia 41, 350–352 (1985). https://doi.org/10.1007/BF02004499
Published:
Issue Date:
DOI: https://doi.org/10.1007/BF02004499