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Reciprocal biological activities of the cyclic tetrapeptides chlamydocin and HC-toxin

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Summary

Chlamydocin, a potent cytostatic agent against cultured mammalian cells, and HC-toxin, a host-specific phytotoxin, are cyclic tetrapeptides containing the same epoxide α-amino acid. We show here that these compounds have reciprocal biological activity; HC-toxin is cytostatic against cultured mastocytoma cells, and chlamydocin has host-specific toxin activity against maize. Chlamydocin and another related cyclic peptide, Cyl-2, are less host-specific than HC-toxin because maize tolerant to HC-toxin is more sensitive to chlamydocin and Cyl-2.

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Authors and Affiliations

  1. Department of Plant Breeding and Biometry, Cornell University, 14853, Ithaca, New York, USA

    J. D. Walton, E. D. Earle, H. Stähelin, A. Grieder, A. Hirota & A. Suzuki

  2. Preclinical Research, Sandoz Ltd, CH-4002, Basel, Switzerland

    J. D. Walton, E. D. Earle, H. Stähelin, A. Grieder, A. Hirota & A. Suzuki

  3. Department of Agricultural Chemistry, University of Osaka Prefecture, 591, Sakai, Japan

    J. D. Walton, E. D. Earle, H. Stähelin, A. Grieder, A. Hirota & A. Suzuki

  4. Department of Agricultural Chemistry, The University of Tokyo, Bunkyo-ku, Tokyo, Japan

    J. D. Walton, E. D. Earle, H. Stähelin, A. Grieder, A. Hirota & A. Suzuki

Authors
  1. J. D. Walton
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  2. E. D. Earle
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  3. H. Stähelin
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  4. A. Grieder
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  5. A. Hirota
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  6. A. Suzuki
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Walton, J.D., Earle, E.D., Stähelin, H. et al. Reciprocal biological activities of the cyclic tetrapeptides chlamydocin and HC-toxin. Experientia 41, 348–350 (1985). https://doi.org/10.1007/BF02004498

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  • DOI: https://doi.org/10.1007/BF02004498

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