Advertisement

Experientia

, Volume 36, Issue 1, pp 133–134 | Cite as

Increase in pituitary melanocyte-stimulating hormone activity of genetically obese (ob/ob) mice

  • Margaret H. Peaslee
  • Beatriz Moisset
  • H. Shibuya
  • Candace B. Pert
Specialia

Summary

Melanocyte-stimulating hormone (MSH) activity was measured in the pituitaries of genetically obese and lean control mice using the frog skin bioassay. Obese mice pituitaries demonstrated very significantly elevated levels of biologically active MSH when compared to their lean littermates. These results support the hypothesis that the elevated levels of pituitary hormones found in obese mice possess true biological activity.

Keywords

Biological Activity Elevated Level Control Mouse Hormone Activity Pituitary Hormone 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

References

  1. 2.
    D.L. Coleman and K.P. Hummel, Diabetologia9, 287 (1973).PubMedGoogle Scholar
  2. 3.
    J.A. Edwardson and C.A.M. Hough, J. Endocr.65, 99 (1975).PubMedGoogle Scholar
  3. 4.
    S. Beevor, A. Beloff-Chain, A. Donaldson and J. A. Edwardson, J. Physiol.275, 55P (1977).Google Scholar
  4. 5.
    D.L. Margules, B. Moisset, M.J. Lewis, H. Shibuya and C.B. Pert, Science202, 988 (1978).PubMedGoogle Scholar
  5. 6.
    K. Shizume, A.B. Lerner and T.B. Fitzpatrick, Endocrinology54, 553 (1954).PubMedGoogle Scholar
  6. 7.
    M.H. Peaslee and S.E. Milburn, J. Endocr.51, 253 (1971).PubMedGoogle Scholar
  7. 8.
    A.J. Kastin, A. Arimura, S. Viosca, L. Barrett and A.V. Schally, Neuroendocrinology2, 200 (1967).Google Scholar
  8. 9.
    R.E. Mains, B.A. Eipper and N. Ling, Proc. natl Acad. Sci. USA74, 3014 (1977).PubMedGoogle Scholar
  9. 10.
    A.P. Scott, J.G. Ratcliffe, L.H. Rees, J. Landon, H.P.J. Bennet, P.J. Lowry and C. McMartin, Nature, New Biol.244, 65 (1973).Google Scholar

Copyright information

© Birkhäuser Verlag 1980

Authors and Affiliations

  • Margaret H. Peaslee
    • 1
    • 2
    • 3
  • Beatriz Moisset
    • 1
    • 2
    • 3
  • H. Shibuya
    • 1
    • 2
    • 3
  • Candace B. Pert
    • 1
    • 2
    • 3
  1. 1.Department of ZoologyLouisiana Tech UniversityRustonUSA
  2. 2.Department of PsychologyTemple UniversityPhiladelphiaUSA
  3. 3.Section of Biochemistry and PharmacologyNational Institutes of Mental HealthBethesdaUSA

Personalised recommendations