Experientia

, Volume 32, Issue 7, pp 911–913 | Cite as

Mitostatic action of 4,6-dimethyl-2-amino-3,4,5-trimethoxyphenyl-pyrimidine on mammalian cells

  • Maria L. Schivo
  • Maria A. Marcialis
  • Ornella Flore
  • S. Dessy
  • A. Garzia
  • B. Loddo
Specialia Anatomica, Histologica, Embryologica, Carcinologica

Summary

4, 6 dimethyl-2-amino-3, 4, 5-trimethoxyphenylpyrimidine arrests the mitotic cycle of mammalian cells in metaphase, both in vitro and in vivo. The mitostatic effect is promptly reverted by interruption of drug treatment.

Keywords

Mammalian Cell Drug Treatment Mitotic Cycle 

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Literatur

  1. 1.
    This work has been supported by a Grant of the Consiglio Nazionale delle Ricerche (Roma).Google Scholar
  2. 2.
    O. J. Eigsti andP. Dustin jr.,Colchicine in Agriculture, Medicine and Chemistry, (Jowa State College Press, Ames, Jowa 1955).Google Scholar
  3. 3.
    S. E. Malawista andK. G. Bensch, Science156, 521 (1967).PubMedGoogle Scholar

Copyright information

© Birkhäuser Verlag 1976

Authors and Affiliations

  • Maria L. Schivo
    • 1
    • 2
  • Maria A. Marcialis
    • 1
    • 2
  • Ornella Flore
    • 1
    • 2
  • S. Dessy
    • 1
    • 2
  • A. Garzia
    • 1
    • 2
  • B. Loddo
    • 1
    • 2
  1. 1.Instituto di Microbiologia II dell'Università degli Studi di CagliariCagliari(Italy)
  2. 2.Istituto Chemioterapico ItalianoLodi(Italy)

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