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The interaction of organic cations with the mitochondrial membrane

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Summary

Weak and strong organic bases behave in an opposite manner in respect to several mitochondrial functions. The former induce a catalytic exchange with K+ in valinomycon-treated, respiratory-inhibited mitochondria, and act as uncouplers in respiring mitochondria. The latter induce a stoicheometric exchange with K+ and are actively taken up by respiring mitochondria.

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Literatur

  1. J. D. Judah, A. E. M. McLean, K. Ahmed andG. S. Cristie, Biochim. biophys. Acta94, 441 (1965).

    Article  CAS  Google Scholar 

  2. A. Azzi andA. Scarpa, Biochim. biophys. Acta135, 1087 (1967).

    Article  CAS  PubMed  Google Scholar 

  3. C. L. Johnson andA. Schwartz, J. Pharmac. exp. Ther.167, 365 (1969).

    CAS  Google Scholar 

  4. S. Papa, F. Guerrieri, S. Simone andM. Lorusso, Bioenergetics3, 553 (1972).

    Article  CAS  Google Scholar 

  5. B. Chance, A. Azzi andL. Mela,The Molecular Basis of Membrane Function (Ed.D. C. Tosteson; Prentice-Hall Inc., Englewood Cliffs, N. Jersey 1969), p. 561.

    Google Scholar 

  6. B. Chance andL. Mela, J. biol. Chem.241, 4588 (1966).

    Article  CAS  PubMed  Google Scholar 

  7. B. Chance, L. Mela andE. J. Harris, Fedn. Proc.27, 902 (1968).

    CAS  Google Scholar 

  8. B. Chance, A. Azzi, L. Mela, G. Radda andH. Vainio, FEBS Lett.3, 10 (1969).

    Article  CAS  PubMed  Google Scholar 

  9. B. Chance andL. Mela,Probes of Structure and Function of Macromolecules and Membranes (Academic Press Inc., New York and London 1971), vol. 1, p. 261.

    Book  Google Scholar 

  10. P. Dell'Antone, R. Colonna andG. F. Azzone, Eur. J. Biochem.24, 553 (1972).

    Article  CAS  PubMed  Google Scholar 

  11. A. R. Crofts, Biochim. biophys. Res. Commun.24, 127 (1966).

    Article  CAS  Google Scholar 

  12. G. Hind andC. P. Whittingham, Biochim. biophys. Acta75, 194 (1963).

    Article  CAS  Google Scholar 

  13. A. R. Crofts, J. biol. Chem.242, 3352 (1967).

    Article  CAS  PubMed  Google Scholar 

  14. M. Montal, M. Nishimura andB. Chance, Biochim. biophys. Acta223, 183 (1970).

    Article  CAS  PubMed  Google Scholar 

  15. R. E. McCarty andC. H. Coleman, Arch. Biochem. Biophys.141, 198 (1970).

    Article  CAS  PubMed  Google Scholar 

  16. H. Löw, Biochim. biophys. Acta32, 1 (1959).

    Article  PubMed  Google Scholar 

  17. L. E. Bakeeva, L. L. Grinius, A. A. Jasaitis, V. V. Kuliene, D. O. Levisky, E. A. Liberman, I. I. Severina andV. P. Skulachev, Biochim. biophys. Acta216, 13 (1970).

    Article  CAS  PubMed  Google Scholar 

  18. E. A. Liberman andV. P. Skulachev, Biochim. biophys. Acta216, 30 (1970).

    Article  CAS  PubMed  Google Scholar 

  19. K. S. Rogers andE. S. Higgins, J. biol. Chem.248, 7142 (1973).

    Article  CAS  PubMed  Google Scholar 

  20. G. P. Brierley, M. Jurkowitz, K. M. Scott andA. J. Merola, J. biol. Chem.245, 5404 (1970).

    Article  CAS  PubMed  Google Scholar 

  21. A. Azzi, B. Chance, G. K. Radda andC. P. Lee, Proc. natn. Acad. Sci., USA62, 612 (1969).

    Article  CAS  Google Scholar 

  22. R. Colonna, S. Massari andG. F. Azzone, Eur. J. Biochem.34, 577 (1973).

    Article  CAS  Google Scholar 

  23. S. Massari, L. Frigeri andG. F. Azzone, J. Membr. Biol.9, 71 (1972).

    Article  CAS  PubMed  Google Scholar 

  24. M. E. Pullman andH. S. Penefsky,Methods in Enzymology (Eds.S. P. Colowick andN. O. Kaplan; Academic Press Inc., New York and London 1963), vol. 6, p. 277.

    Google Scholar 

  25. S. Massari andT. Pozzan, Arch. Biochem. Biophys.173, 332 (1976).

    Article  CAS  PubMed  Google Scholar 

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Authors and Affiliations

  1. C.N.R. Unit for the Study of Physiology of Mitochondria and Institute of General Pathology, University of Padova, Via Loredan 16, I-35100, Padova, Italy

    S. Massari & T. Pozzan

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  1. S. Massari
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  2. T. Pozzan
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Massari, S., Pozzan, T. The interaction of organic cations with the mitochondrial membrane. Experientia 32, 868–869 (1976). https://doi.org/10.1007/BF02003735

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  • DOI: https://doi.org/10.1007/BF02003735

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