Summary
By incubation of human erythrocyte ghosts with cholesterol oxidase (EC 1.1.3.6) part of the cholesterol of the membrane is replaced by 4-cholesten-3-one. This alteration in the sterol composition is accompanied by an inhibition of the (Na+, K+) ATPase of the erythrocyte membrane.
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Literatur
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Acknowledgments. This study was supported by the Deutsche Forschungsgemeinschaft Bonn-Bad Godesberg and the Sonderforschungsbereich 90 of the University of Heidelberg. We thank Mr.J. Schmidt and MissI. Geldmacher for skilful technical assistance.
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Seiler, D., Fiehn, W. Effect of cholesterol oxidation on (Na+, K+) ATPase activity of erythrocyte membranes. Experientia 32, 849–850 (1976). https://doi.org/10.1007/BF02003723
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DOI: https://doi.org/10.1007/BF02003723