Summary
Prolonged administration of glibenclamide decreased blood sugar, liver glycogen and protein and increased liver and serum lipids and organic phosphates of liver in normal rats. A significant weight increase observed in glibenclamide group of rats is attributed to lipid accumulation.
Similar content being viewed by others
Literatur
A. Loubatières, Proc. R. Soc. Med.53, 595 (1960).
A. Hasselblatt andJ. Schmieta, Klin. Wschr.39, 910 (1961).
H. N. Antoniades, H. M. Pyle andJ. A. Bougas, Diabetes11, 34 (1962).
J. Madsen, Acta med. scand.476, 109 (1967).
J. M. Feldman andH. E. Lebovitz, Arch. intern. Med.123, 314 (1969).
M. B. Bhide andR. Aiman, Indian J. med. Res.51, 733 (1963).
K. T. Augusti andP. A. Kurup, Indian. J. Biochem.4, 87 (1967).
C. R. Lopez Quijada, R. Candela andJ. L. R. Candela, Medicina exp.6, 65 (1962).
R. E. Miller, F. E. Wherry andJ. W. Mason, Endocrinology79, 207 (1966).
R. F. Bradley, Ann. N.Y. Acad. Sci.82, 513 (1959).
P. D. Bewsher andJ. Ashmore, Biochem. biophys. Res. Commun.24, 431 (1966).
L. Weiss, W. Guder andO. Wieland, 3. Kongr. dt. Diabetes-Ges. Göttingen 1968, p. 15 (abstract).
J. C. Shipp, F. C. Wood, Jr. andM. Alexander, J. Am. med. Ass.188, 468 (1964).
K. Prasannan andK. T. Augusti, Indian J. med. Res.61, 1072 (1973).
J. M. Foy andV. F. Standing, Experientia29, 1006 (1973).
K. Prasannan andP. A. Kurup, Indian J. Biochem. Biophys.10, 42 (1973).
A. Loubatières, M. M. Mariani, G. Ribes, H. De Malbosc andJ. Chapel, Diabetologia5, 1 (1969).
N. V. Carrol, R. V. Longley andJ. H. Roe, J. biol. Chem.220, 583 (1956).
K. T. Augusti andP. T. Mathew, Experientia30, 468 (1974).
A. Asatoor andE. J. King, Biochem. J.56, 44 (1954).
M. Somogyi, J. biol. Chem.195, 19 (1952).
O. H. Lowry, N. J. Rosebrough, A. L. Farr andR. J. Randall, J. biol. Chem.193, 265 (1951).
O. Folin andV. Ciocalteu, J. biol. Chem.73, 627 (1927).
S. Moore andW. H. Stein, J. biol. Chem.176, 367 (1948).
C. Entenman, inMethods in Enzymology (Eds.S. P. Colowick andN. O. Kaplan; Academic Press, New York 1957), vol. 3., p. 299.
W. M. Sperry andF. C. Brand, J. biol. Chem.213, 69 (1955).
J. J. Carr andI. Drekter, J. clin. Chem.2, 353 (1956).
R. Schoenheimer andW. M. Sperry, J. biol. Chem.106, 725 (1934).
P. G. Ackerman andG. Toro, inGradwhol's Clinical Laboratory Methods and Diagnosis (Eds.S. Frankel andS. Reitman; Mosby, St. Louis 1963), vol. 1., p. 249.
E. Vanhandel andD. B. Zilversmit, J. Lab. clin. Med.50, 152 (1967).
C. H. Fiske andY. Subba Row, J. biol. Chem.66, 375 (1925).
L. F. Leloir andC. E. Cardini, inMethods in Enzymology (Eds.S. P. Colowick andN. O. Kaplan; Academic Press, New York 1957), vol. 3., p. 843.
L. R. Dechatelect andH. I. McDonald, Proc. Soc. exp. Biol. Med.127, 415 (1968).
J. D. Brown, D. B. Stone andA. A. Steele, Metabolism18, 926 (1969).
K. T. Augusti andP. A. Kurup, Indian J. Biochem.5, 76 (1968).
K. T. Augusti, Indian J. Biochem. Biophys.10, 130 (1973).
A. White, P. Handler andE. L. Smith, inPrinciples of Biochemistry, 3rd ed. (The Blackiston Division, McGraw-Hill Book Company, New York 1964), p. 455.
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
George, A.V., Augusti, K.T. Effects of long-term feeding of glibenclamide on normal rats. Experientia 32, 846–847 (1976). https://doi.org/10.1007/BF02003721
Published:
Issue Date:
DOI: https://doi.org/10.1007/BF02003721