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On the possible role of different endogenous opiate receptors in gastroduodenal ulceration of the rat

Agents and Actions volume 31, pages 164–169 (1990)Cite this article

Abstract

In Wistar rats of both sexes stress(restraint)- and drug (indomethacin)-induced gastric, as well, as cysteamine-induced duodenal ulceration was treated by morphine and nalorphine, given either alone or in combination.

Neither morphine nor nalorphine had a significant anti-ulcerogenic effect. In contrast, the combined morphine+nalorphine treatment showed a highly significant anti-ulcerogenic action in the case of gastric ulceration but it was ineffective on duodenal ulcer formation. It seems that the ν and δ endogenous opiate receptors play a significant role in the anti-ulcerogenic effect, while the μ receptors are involved to a considerably lesser degree.

Moreover, the experimental results strengthen the view that gastric and duodenal ulceration are two different pathological entities and that ulcer formation is only a common consequence.

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References

  1. J. Nafradi, G. A. Balint and V. Varro,The effect of naloxone in different gastroduodenal ulcer models. Acta Physiol Hung61, 95–98 (1983).

    PubMed  Google Scholar 

  2. E. J. Simon and J. M. Hiller,The opiate receptors. Ann Rev Pharmacol.18, 371–394 (1978).

    Google Scholar 

  3. A. Goldstein and I. F. James,Multiple opioid receptors. Criteria for identification and classification. TIPS.5, 503–505 (1984).

    Google Scholar 

  4. K. J. Chang, B. R. Cooper, E. Hazum and P. Cuatrecasas,Multiple opiate, receptors: different regional distribution in the brain and differential binding of opiates and opioid peptides. Mol Pharmacol16, 91–104 (1979).

    PubMed  Google Scholar 

  5. D. R. Jasinski,Effects in man of partial morphine agonists. InAgonist and Antagonist Actions of Narcotic Analgesis Drugs. (Eds. H. W. Kosterlitz, H. O. J. Collier and J. E. Villareal) pp 94–103., University Park Press, Baltimore, 1973.

    Google Scholar 

  6. G. A. Balint and V. Varro,Actinomycin inhibits, gastric mucosal protection by prostacyclin in rats. Prostaglandins,21, 255–258 (1981).

    PubMed  Google Scholar 

  7. G. A. Balint, Gizella, Karacsony and V. Varro,The effect of long-term prostacyclin treatment on the protein, DNA and RNA content of rat gastric fundic mucosa. Agents and Actions16, 404–406 (1985).

    PubMed  Google Scholar 

  8. S. Szabo,Animal model of human disease: Cysteamine-induced acute and chronic duodenal ulcer in the rat. Am J Path93, 273–276 (1978).

    PubMed  Google Scholar 

  9. J. Nafradi, G. A. Balint, S. Csati and V. Varro,Gastrointestinal mucosal gamma-glutamyl transpeptidase activity changes in different ulcer models of rat. Agents and Actions15, 459–550 (1984).

    PubMed  Google Scholar 

  10. J. Nafradi, G. A. Balint and V. Varro,The effect of prostacyclin and its analogues on cysteamine-induced duodenal ulceration of rats. Acta Med Hung45, 127–130 (1988).

    PubMed  Google Scholar 

  11. R. Virchow,Historisches, Kritisches und Positives zur Lehre der Unterleibsaffektionen. Arch path Anat5, 281–375 (1853).

    Google Scholar 

  12. M. Feldman and Y. M. Cowley,Effect of opiate antagonist (Naloxone) on the gastric acid secretory respone to sham feeding, pentagastrin and histamine in man. Dig Dis Sci27, 308–310 (1982).

    PubMed  Google Scholar 

  13. A. Ray, P. G. Henke and R. M. Sullivan,Opiate mechanisms in the central amygdala and gastric stress pathology in rats. Brain Res442, 195–198 (1988).

    PubMed  Google Scholar 

  14. J. Lord, A. A. Waterfield, J. Hughes and H. W. Kosterlitz,Endogenous opioid peptides: Multiple agonists and receptors. Nature267, 495–499 (1977).

    PubMed  Google Scholar 

  15. R. F. Ambinder and M. M. Schuster,Endorphins: New gut peptides with a familiar face, Gastroenterology,77, 1132–1140 (1979).

    PubMed  Google Scholar 

  16. K. J. Chang and P. Cuatrecasas,Multiple opiate receptors. J biol Chem254, 2610–2618 (1979).

    PubMed  Google Scholar 

  17. W. R. Martin, C. G. Eades, J. A. Thompson, R. E. Huppler and P. E. Gilbert,The effects of morphine- and nalorphine-like drugs in the non-dependent and morphine-dependent chronic spinal dog. J Pharm Exp Therap197, 517–532 (1976).

    Google Scholar 

  18. P. E. Gilbert and W. R. Martin,The effect of morphine- and nalorphine-like drugs in the non-dependent, morphine-dependent and cyclazocine-dependent chronic spinal dog. J Pharm Exp Therap198, 66–83 (1976).

    Google Scholar 

  19. S. H. Snyder and S. R. Childers,Opiate receptors and opioid peptides. Ann Rev Neurosci2, 35–64 (1979).

    PubMed  Google Scholar 

  20. M. M. Ho, S. Dai and C. W. Ogle,Decreased acid secretion and gastric lesion production by morphine in rats. Eur J Pharmacol102, 117–121 (1984).

    PubMed  Google Scholar 

  21. M. M. Ho, C. W. Ogle and S. Dai,Effects of morphine, hypoxaemia and hypercapnia on the rat stomach. Eur J Pharmacol126, 103–109 (1986).

    PubMed  Google Scholar 

  22. M. Del Tacca, C. Bernadini, E. Corsano, G. Soldani and C. Roze,Effects of morphine on gastric ulceration, barrier mucus and acid secretion in pylorus-ligated rats. Pharmacology35, 174–180 (1987).

    PubMed  Google Scholar 

  23. W. Kromer,Endogenous and exogenous opioids in the control of gastrointestinal motility and secretion. Pharmacol Rev40, 121–162 (1988).

    PubMed  Google Scholar 

  24. Y. Waisman, G. Dinari, H. Marcus, M. Ligumsky, Y. Rosenbach, I. Zahavi, and M. Nitzan,Naloxone is protective against indomethacin-induced intestinal ulceration in the rat. Gastroenterology89, 86–91 (1985).

    PubMed  Google Scholar 

  25. M. B. Gupta, G. P. Gupta and K. P. Bhargava,Role of opioid receptors in stress-induced gatric ulceration in rats. Indian J Med Res83, 532–535 (1986).

    PubMed  Google Scholar 

  26. B. Stenquist, T. Lind, U. Haglund, J. J. Holst, J. F. Rehfeld and L. Olbe,Do enkephalins participate in vagal activation of gastric acid secretion in man? Regul Pept17, 1–7 (1987).

    PubMed  Google Scholar 

  27. S. Archer, N. F. Albertson and A. K. Pierson,Structure-activity relationship in the opioid antagonists. InAgonist and Antagonist Actions of Narcotic Analgesic Drugs. (Eds. H. W. Kosterlitz, H. O. J. Collier and J. E. Villareal) pp 25–29, University Park Press, Baltimore 1973.

    Google Scholar 

  28. L. S. Harris,Narcotic antagonists: Structure-activity relationships. InNarcotic Antagonists. (Eds. M. C. Braude, L. S. Harris, E. L. May, P. J. Smith and J. E. Villareal) pp 13–20, Raven Press, New York 1974.

    Google Scholar 

  29. G. Barret, M. Trsic and R. E. Willette (Eds),QuaSAR: Quantitative Structure Activity Relationships of Analgesics, Narcotic Antagonists and Hallucinogens. NIH on Drug Abuse Res Mongraph No. 22. US Govt Printing Office, Washington, 1978.

    Google Scholar 

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Author notes

  1. G. A. Balint

    Present address: Dept. of Pharmacology, (S. P.), Addis Ababa University, Addis Ababa, Ethiopia

Affiliations

  1. First Department of Medicine, Albert Szent-Györgyi Medical University, G.P.O. Box 469, Szeged, Hungary

    G. A. Balint & J. Nafradi

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  1. G. A. Balint
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  2. J. Nafradi
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Balint, G.A., Nafradi, J. On the possible role of different endogenous opiate receptors in gastroduodenal ulceration of the rat. Agents and Actions 31, 164–169 (1990). https://doi.org/10.1007/BF02003238

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  • DOI: https://doi.org/10.1007/BF02003238

Keywords

  • Morphine
  • Significant Role
  • Indomethacin
  • Duodenal Ulceration
  • Gastric Ulceration