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, Volume 31, Issue 1–2, pp 96–101 | Cite as

Differential effects of captopril and enalapril, two angiotensin converting enzyme inhibitors, on immune reactivity in experimental lupus disease

  • A. Tarkowski
  • H. Carlsten
  • H. Herlitz
  • G. Westberg
Inflammation and Immunomodulation Letters to the Editors


We have previously demonstrated that Captopril, an inhibitor of angiotensin converting enzyme (ACE), ameliorates experimental systemic lupus erythematosus in inbred MRL lpr/lpr (MRL/l) mice. In contrast, Enalapril, another ACE inhibitor with antihypertensive properties but lacking a thiol group, did not show similar beneficial effects. To better understand the mode of action of captopril in the autoimmune disease we have evaluated its immunomodulatory properties with special emphasis on antigen-specific and polyclonal B- and T-cell activation. The results obtained strongly suggest that Captopril exerts its immunomodulatory effects through stimulation of T-lymphocytes.


Immune Reactivity Systemic Lupus Erythematosus Angiotensin Autoimmune Disease Thiol 
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Copyright information

© Birkhäuser Verlag 1990

Authors and Affiliations

  • A. Tarkowski
    • 1
    • 2
  • H. Carlsten
    • 1
    • 2
  • H. Herlitz
    • 3
  • G. Westberg
    • 3
  1. 1.Department of Clinical ImmunologyUniversity of GöteborgGöteborgSweden
  2. 2.Department of RheumatologyUniversity of GöteborgGöteborgSweden
  3. 3.Department of NephrologyUniversity of GöteborgGöteborgSweden

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