Advertisement

Agents and Actions

, Volume 31, Issue 1–2, pp 96–101 | Cite as

Differential effects of captopril and enalapril, two angiotensin converting enzyme inhibitors, on immune reactivity in experimental lupus disease

  • A. Tarkowski
  • H. Carlsten
  • H. Herlitz
  • G. Westberg
Inflammation and Immunomodulation Letters to the Editors

Abstract

We have previously demonstrated that Captopril, an inhibitor of angiotensin converting enzyme (ACE), ameliorates experimental systemic lupus erythematosus in inbred MRL lpr/lpr (MRL/l) mice. In contrast, Enalapril, another ACE inhibitor with antihypertensive properties but lacking a thiol group, did not show similar beneficial effects. To better understand the mode of action of captopril in the autoimmune disease we have evaluated its immunomodulatory properties with special emphasis on antigen-specific and polyclonal B- and T-cell activation. The results obtained strongly suggest that Captopril exerts its immunomodulatory effects through stimulation of T-lymphocytes.

Keywords

Immune Reactivity Systemic Lupus Erythematosus Angiotensin Autoimmune Disease Thiol 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. [1]
    J. Lieberman,Elevation of serum angiotensin-converting enzyme (ACE) level in sarcoidosis. Am. J. Med.59, 365–372 (1975).PubMedGoogle Scholar
  2. [2]
    H. Herlitz, A. Tarkowski, C. Svalander, R. Volkmann and G. Westberg,Beneficial effect of captopril on systemic lupus erythematosus-like disease in MRL lpr/lpr mice. Int. Archs Allergy appl. Immun.85, 272–277 (1988).Google Scholar
  3. [3]
    H. Herlitz, C. Svalander, A. Tarkowski and G. Westberg,Influence of antihypertensive treatment on renal and extrarenal lupus manifestations in MRL/l mice. Scand. J. Urology Nephr. (S)108, 65–70 (1988).Google Scholar
  4. [4]
    H. Van Loveren, K. Kato, R. E. Ratzlaff, R. Meade, W. Ptak and P. A. Askenase,Use of micrometers and calipers to measure various components of delayed-type hypersensitivity ear swelling reactions in mice. J. Immunol. Meth.67, 311–319 (1984).Google Scholar
  5. [5]
    H. Carlsten, L.-Å. Nilsson and A. Tarkowski,Impaired cutaneous delayed-type hypersensitivity in autoimmune MRL lpr/lpr mice. Int. Archs Allergy appl. Immun.81, 322–325 (1986).Google Scholar
  6. [6]
    A. Tarkowski, R. Jonsson, R. Sanchez, L. Klaresog and W. J. Koopman,Features of renal vasculitis in autoimmune MRL lpr/lpr mice: phenotypes and functional properties of infiltrating cells. Clin. exp. Immunol.72, 91–97 (1988).PubMedGoogle Scholar
  7. [7]
    H. Carlsten and A. Tarkowski,Expression of heterozygous lpr gene in MRL mice. I. Defective T-cell reactivity and polyclonal B-cell activation. Scand. J. Immunol.30, 457–462 (1989).PubMedGoogle Scholar
  8. [8]
    S. Gillis, M. M. Ferm, W. Ou and K. A. Smith,T-cell growth factor: parameters of production and quantitative microassay for activity. J. Immunol.120, 2027–2031 (1978).PubMedGoogle Scholar
  9. [9]
    N. Lycke, A.-K. Bromander, L. Ekman, U. Karlsson and J. Holmgren,Cellular basis of immunomodulation by cholera toxin in vitro with possible association to the adjuvant function in vivo. J. Immunol.142, 20–27 (1989).PubMedGoogle Scholar
  10. [10]
    G. Mancini, A. O. Carbonara and J. F. Heremans,Immunochemical quantitation of antigens by single radial immunodiffusion. Immunochemistry2, 235–254 (1965).PubMedGoogle Scholar
  11. [11]
    R. T. Wold, F. E. Young, E. M. Tan and R. S. Farr,Deoxyribonucleic acid antibody: a method to detect its primary interaction with deoxyribonucleic acid. Science161, 806–807 (1968).PubMedGoogle Scholar
  12. [12]
    G. Lindstedt, P.-A. Lundberg, S. Ivarson and J. Lindberg,Circulating heat-labile DNA binder(s) in chronic active hepatitis and rheumatoid arthritis. Clin. Chim. Acta62, 183–186 (1975).PubMedGoogle Scholar
  13. [13]
    M. W. Russel, T. A. Brown, J. Radl, J. J. Haaijman and J. Mestecky, Assay of human IgA subclass antibodies in serum and secretions by means of monoclonal antibodies. J. Immunol. Methods87, 87–93 (1986).PubMedGoogle Scholar
  14. [14]
    H. Elwing and H. Nygren,Diffusion-in-gel enzyme-linked immunosorbent assay (DIG-ELISA): a simple method for quantitation of class-specific antibodies. J. Immunol. Methods31, 101–108 (1979).PubMedGoogle Scholar
  15. [15]
    A. Tarkowski, C. Czerkinsky and L.-Å. Nilsson,Detection of IgG rheumatoid factor secreting cells in autoimmune MRL/l mice: a kinetic study. Clin. exp. Immunol.58, 7–12 (1984).PubMedGoogle Scholar
  16. [16]
    J. P. Henry, J. B. Meehan, P. Stephens and G. A. Santesteban,Arterial pressure in CBA mice as related to age. J. Geront.20, 239–243 (1965).PubMedGoogle Scholar
  17. [17]
    D. Wofsy and W. E. Seaman,Successful treatment of autoimmunity of NZB/NZW F1 mice by treatment with monoclonal antibody to L3T4. J. Exp. Med.161, 378–391 (1985).PubMedGoogle Scholar
  18. [18]
    W. E. Seaman, D. Wofsy, S. Greenspan and J. A. Ledbetter,Treatment of autoimmune MRL/lpr mice with monoclonal antibody to Thy-1.2: a single injection has sustained effects on lymphoproliferation and renal disease. J. Immunol.130, 1713–1718 (1983).PubMedGoogle Scholar
  19. [19]
    C. Scott, M. Tsurfuji, C. Lu, R. Finberg and M.-S. Sy,Comparison of antigen-specific T-cell responses in autoimmune MRL MP-lpr/lpr and MRL Mp +/+ mice. J. Immunol.132, 633–639 (1984).PubMedGoogle Scholar
  20. [20]
    G. S. Deepe, C. L. Taylor, L. Srivastava and W. E. Bullock,Impairment of granulomatous inflammatory response to histoplasma capsulatum by inhibitors of angiotensin-converting enzyme. Infect. Immunity48, 395–401 (1985).Google Scholar
  21. [21]
    S. A. Johnsen and M. Aurell,Immunosuppressive action of captopril blocked by prostaglandin synthetase inhibitor. Lancet1, 1005 (1981).Google Scholar
  22. [22]
    G. J. Prud'homme, T. M. Fieser, F. J. Dixon and A. N. Theofilopoulos,B-cell tropic interleukins in murine systemic lupus erythematosus (SLE) 1. Immunol. Rev.78, 159–183 (1984).PubMedGoogle Scholar
  23. [23]
    M. Kiyotaki, T. Toguchi, T. Abe, T. Takeuchi, C. Morimoto and M. Homma,In vitro anti-DNA antibody synthesis by peripheral blood lymphocytes in patients with systemic lupus erythematosus. Clin. Immunol. Immunopath.21, 237–246 (1981).Google Scholar
  24. [24]
    J. F. Delfraissy, P. Galanaud, J. F. Balavoine, C. Wallon and J. Dormont,Captopril and immune regulation. Kidney Int.25, 925–929 (1984).PubMedGoogle Scholar

Copyright information

© Birkhäuser Verlag 1990

Authors and Affiliations

  • A. Tarkowski
    • 1
    • 2
  • H. Carlsten
    • 1
    • 2
  • H. Herlitz
    • 3
  • G. Westberg
    • 3
  1. 1.Department of Clinical ImmunologyUniversity of GöteborgGöteborgSweden
  2. 2.Department of RheumatologyUniversity of GöteborgGöteborgSweden
  3. 3.Department of NephrologyUniversity of GöteborgGöteborgSweden

Personalised recommendations