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European Journal of Pediatrics

, Volume 155, Issue 9, pp 820–822 | Cite as

Sedation for children undergoing magnetic resonance imaging: Efficacy and safety of rectal thiopental

  • R. P. Beekman
  • T. M. Hoorntje
  • F. J. A. Beek
  • R. H. Kuijten
Pharmacology

Abstract

Abstract

The need to reappraise sedation policy is dictated by newer noninvasive imaging modalities. In this study we evaluate the safety and efficacy of rectally-administered thiopental in children undergoing MRI. Eighty-three consecutive patients with congenital heart disease (mean age 2.9 years, SD 2.5) undergoing MRI evaluation of the heart were given thiopental (2.5–50 mg/kg, 700 mg max) per rectum. In order to prevent leakage, a female urinary catheter was used. In 79 patients (95.2%) successful sedation was achieved and adequate MR imaging could be obtained. In 4 patients (4.8%) the sedation was inadequate. Respiratory depression was not encountered in any of the patients. The presence of cyanotic congenital heart disease in 26 patients had no influence on the safety and efficacy of thiopental. All successfully sedated children were asleep within 30 min and adequate sedation was maintained for at least 45 min. All patients could be aroused within 90 min, and sent home thereafter. Minor side-effects occurred in two patients.

Conclusion

Rectally-administered thiopental is a safe and effective sedative drug with a duration of action tailored to performing MRI.

Keywords

Magnetic Resonance Imaging Catheter Heart Disease Imaging Modality Congenital Heart Disease 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    American Academy of Pediatrics, Committee on Drugs (1992) Guidelines for monitoring and management of pediatric patients during and after sedation for diagnostic and therapeutic procedures. Pediatrics 89:1110–1115Google Scholar
  2. 2.
    Burkart GJ, White TJ, Siegle RL, Jabbour JT, Ramey DR (1980) Rectal thiopental versus and intramuscular cocktail for sedating children before CT. Am J Hosp Pharm 37:222–224PubMedGoogle Scholar
  3. 3.
    Coté CJ (1994) Sedation for the pediatric patient. Pediatr Clin North Am 41:31–58PubMedGoogle Scholar
  4. 4.
    Goodman LS, Gilman A (1975) The pharmacological basis of therapeutics, 5th edn. Macmillan Publishing Co., Inc. New York, p 117Google Scholar
  5. 5.
    Greenberg SB, Faerber EN, Radke JL, Aspinal CL, Adams RC, Mercer-Wilson DD (1994) Sedation of difficult-to-sedate children undergoing MR imaging: value of thioridazine as an adjunct to chloral hydrate. AJR 163:165–168PubMedGoogle Scholar
  6. 6.
    Greenberg SB, Faerber EN, Aspinal CL, Adams RC (1993) High-dose chloral hydrate sedation for children under-going MR imaging. AJR 161:639–641PubMedGoogle Scholar
  7. 7.
    Keeter S, Benator BM, Weinberg SM, Hartenberg MA (1990) Sedation in pediatric CT: national survey of current practice. Radiology 175:745–752PubMedGoogle Scholar
  8. 8.
    Manuli MA, Davies L (1994) Rectal methohexital for sedation of children during imaging procedures. AJR 160: 577–580Google Scholar
  9. 9.
    O'Brien JF, Falk JL, Carey BE, Malone LC (1991) Rectal thiopental compared with intramuscular meperidine, promethazine, and chlorpromazine for pediatric sedation. Ann Emerg Med 20: 644–647PubMedGoogle Scholar
  10. 10.
    Reynolds JEF (ed) (1993) Martindale the extra pharmacopoeia, 13th edn. The Pharmaceutical Press, London, p 920Google Scholar
  11. 11.
    Smith MT (1990) Chloral hydrate warning. Science 250:359Google Scholar
  12. 12.
    White TJ, Siegle RL, Burckart GJ, Ramey DR (1979) Rectal thiopental for sedation of children for computed tomography. J Comput Assist Tomogr 3:286–288PubMedGoogle Scholar

Copyright information

© Springer-Verlag 1996

Authors and Affiliations

  • R. P. Beekman
    • 1
  • T. M. Hoorntje
    • 2
  • F. J. A. Beek
    • 3
  • R. H. Kuijten
    • 4
  1. 1.Department of Paediatric Cardiology, Wilhelmina Children's HospitalUniversity of UtrechtUtrechtThe Netherlands
  2. 2.Department of Paediatric CardiologyUniversity Hospital of MaastrichtMaastrichtThe Netherlands
  3. 3.Department of RadiologyUniversity Hospital of UtrechtUtrechtThe Netherlands
  4. 4.Department of PaediatricsUniversity Hospital of MaastrichtMaastrichtThe Netherlands

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