The preventive effect of maternal avoidance of cow's milk and eggs on the development of atopic dermatitis and sensitization to food allergens was studied in a prospective trial with families at high risk for atopy. intervention included encouraging exclusive breast feeding for at least 3 months and delaying the controlled introduction of solid foods. In addition, one group received a maternal diet with the complete avoidance of milk and eggs in the last trimester of pregnancy and during the period of exclusive breast feeding, another group had the same diet starting after delivery, and mothers of the third group had no dietary restrictions. The period prevalences of atopic dermatitis as well as the rates of specific sensitization to eggs and milk at 6 and 12 months were not significantly different between groups. We were unable to demonstrate a significant preventive effect of maternal diet.
While breast feeding should be promoted for children at risk for atopy, mothers can be encouraged to stay on normal diet during pregnancy and the breast feeding period.
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Arshad SH, Matthews S, Grant C, Hide D (1992) Effect of allergen avoidance on development of allergic disorders in infancy. Lancet 339:1493–1497
Bergmann RL, Forster J, Schulz J, Bergmann KE, Bauer CP, Wahn U (1993) Atopic family history. Validation of instruments in a multicenter cohort study. Pediatr Allergy Clin Immunol 4:130–135
Bergmann RL, Bergmann KE, Lau S, Luck W, Dannemann A, Bauer CP, Dorsch W, Forster F, Schmidt E, Wahn U (1994) Atopic discases in infancy. The German multicenter atopy study (MAS-90). Pediatr Allergy Immunol 5: [Suppl 1] 19–25
Businco L, Dreborg S, Einarsson R, Giampietro PG, H st A, Keller KM, Strobel S, Wahn U (1993) Hydrolysed milk formulae. Allergenicity and use in treatment and prevention. An ESPACI position paper. Pediatr Allergy Immunol 4:101–111
Cant AJ, Bailes JA, Marsden RA, Hewitt D (1985) Egg and milk hypersensitivity in exclusively breast fed infants with eczema, and detection of egg protein in breast milk. BMJ 291:932–935
Fälth-Magnusson K, Kjellman NIM (1992) Allergy prevention by maternal elimination diet during late pregnancy — a 5-year follow-up of a randomized study. J Allergy Clin Immunol 89:709–713
Fergusson DM, Horwood J, Shannon FT (1990) Early solid feeding and recurrent childhood eczema: a 10-year longitudinal study. Pediatrics 86:541–546
Ford K, Labbock M (1990) Who is breast-feeding? Implication of associated social and biomedical variables for research on the consequences of method of infant feeding. Am J Clin Nutr 52:451–456
Grulee GC, Sanford HN (1936) The influence of breast and artifical feeding on infantile eczema. J Pediatr 9:223–225
Hattevig G, Kjellman B, Sigurs N (1989) The effect of maternal avoidance of eggs, milk, and fish during lactation upon allergic manifestations in infants. Clin Exp Allergy 19:27–32
Kimpen J, Callaert H, Embrechts P, Bosmans E (1987) Cord blood IgE and month of birth. Arch Dis Child 62:478–482
Lilja G, Dannaeus A, Fälth-Magnusson K, Graf-Lonnevig V, Johansson SGO, Kjellman NIM (1988) Immune response of the atopic women and fetus: effect of high- and low-dose food allergen intake during late pregnancy. Clin Allergy 18:131–142
Ribadeau-Dumas B (1988) Structure and variabilty of milk proteins. In: Barth CA, Schlimme E (eds) Milk protein. Nutritional, clinical functional and technological aspects. Steinkopff Verlag Darmstadt. Springer Verlag New York, pp 112–123
Zeiger RS, Heller S, Mellon M, O'Connor R, Hamburger RN (1986) Effectiveness of dietary manipulation in the prevention of food allergy in infants. J Allergy Clin Immunol 78:224–238
Zeiger RS, Heller S, Mellon MH, Forsythe AB, O'Connor RD, Hamburger RN, Schatz M (1989) Effect of combined maternal and infant food-allergen avoidance on development of atopy in early infancy: a randomized study. J Allergy Clin Immunol 84:72–89
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Herrmann, M.E., Dannemann, A., Grüters, A. et al. Prospective study on the atopy preventive effect of maternal avoidance of milk and eggs during pregnancy and lactation. Eur J Pediatr 155, 770–774 (1996). https://doi.org/10.1007/BF02002904