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Potentiation by crude kallikrein of the myotropic effect of angiotensin I in the isolated rabbit aortic strip

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Summary

Crude kallikrein (Padutin®), but not pure kallikrein, when preincubated with angiotensin I caused a potentiation of the myotropic effect of decapeptide on the isolated continuously superfused rabbit aortic strip. Addition of converting enzyme inhibitor, SQ 20881, to the medium inhibited this potentiation. The potentiation by crude kallikrein of the myotropic effect of angiotensin I is probably due to the conversion of decapeptide to octapeptide angiotensin II. This study indicates that Padutin is not a pure kallikrein preparation and probably contains a kininase fraction which causes the conversion of angiotensin I.

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Authors and Affiliations

  1. Department of Pharmacology, Faculty of Medicine, University of Ankara, Ankara, Turkey

    Z. S. Ercan & R. K. Türker

Authors
  1. Z. S. Ercan
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  2. R. K. Türker
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Additional information

The authors are greatful to Prof. G. L. Haberland, Bayer AG, Elberfeld (BRD), for his generous gift of pure Kallikrein® KZC 1/75; to Bayer, Leverkusen (BRD), for Padutin® and to Squibb, New Jersey, USA, for SQ 20881. This work is supported in part by Eczacibaşi Research Foundation, Levent, Istanbul, Turkey. The technical assistance of Mr. M. Kabaçam is greatly appreciated.

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Ercan, Z.S., Türker, R.K. Potentiation by crude kallikrein of the myotropic effect of angiotensin I in the isolated rabbit aortic strip. Experientia 33, 369–370 (1977). https://doi.org/10.1007/BF02002832

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