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[2-o-Iodotyrosine]-oxytocin and [2-o-methyltyrosine]-oxytocin: Basic pharmacology and comments on their potential use in binding studies

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Summary

Both [2-o-iodotyrosine]-oxytocin and [2-o-methyltyrosine]-oxytocin display only weak vasopressor and antidiuretic effects on rats. They inhibit the in vitro uterotonic action of oxytocin; this inhibition is not fully competitive. It is concluded that they are not suitable as markers for studies of uterine receptor for oxytocin.

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Authors and Affiliations

  1. Institute of Molecular Biology and Biophysics, Swiss Federal Institute of Technology, CH-8093, Zürich, Switzerland

    V. Pliška, P. Marbach, Jelena Vašák & J. Rudinger

Authors
  1. V. Pliška
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  2. P. Marbach
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  3. Jelena Vašák
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  4. J. Rudinger
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Additional information

Supported by the Swiss National Science Foundation, grant No. 3.2080.73.

Deceased 30 April 1975.

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Pliška, V., Marbach, P., Vašák, J. et al. [2-o-Iodotyrosine]-oxytocin and [2-o-methyltyrosine]-oxytocin: Basic pharmacology and comments on their potential use in binding studies. Experientia 33, 367–369 (1977). https://doi.org/10.1007/BF02002831

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  • DOI: https://doi.org/10.1007/BF02002831

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