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The effect of vinblastin and vincristin on single nerve fibres

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Summary

The perfusion of the node of Ranvier with vinblastin or vincristin reduces the amplitude of the action potential within a few seconds. Vincristins is 10fold more active than vinblastin. Upon withdrawal, the effect is promptly reversible and it is antagonized by acetylcholine.

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Authors and Affiliations

  1. Institute of Pharmacology, University of Bari, I-70124, Bari, Italy

    Delia Mitolo-Chieppa

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  1. Delia Mitolo-Chieppa
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Mitolo-Chieppa, D. The effect of vinblastin and vincristin on single nerve fibres. Experientia 33, 366–367 (1977). https://doi.org/10.1007/BF02002830

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  • DOI: https://doi.org/10.1007/BF02002830

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