, Volume 33, Issue 3, pp 317–319 | Cite as

Interaction of platinum compounds with bacterial DNA

  • M. Tamaro
  • S. Venturini
  • C. Eftimiadi
  • C. Monti-Bragadin


The cis and trans isomer of PtCl2(NH3)2, cis-Pt(cpa)2Cl2 and 2 platinum pyrimidine blues have been used in a number of bacterial tests indicative of their interaction with bacterial DNA.


Platinum Pyrimidine Trans Isomer Platinum Compound PtCl2 


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 2.
    D. J. Beck and R. R. Brubaker, Mut. Res.27, 181 (1974).Google Scholar
  2. 3.
    C. Monti-Bragadin, M. Tamaro and E. Banfi, Chem. Biol. Int.11, 469 (1975).Google Scholar
  3. 4.
    E. Renshow and A. J. Thomson, J. Bacteriol.94, 1915 (1967).PubMedGoogle Scholar
  4. 5.
    S. Reslova, Chem. Biol. Int.4, 66 (1971).Google Scholar
  5. 6.
    D. J. Beck and R. R. Brubaker, J. Bacteriol.116, 1247 (1973).PubMedGoogle Scholar
  6. 7.
    C. Monti-Bragadin, L. Ramani, L. Samer, G. Mestroni and G. Zassinovich, Antimicrob. ag. Chemother.7, 825 (1975).Google Scholar
  7. 8.
    B. Rosenberg, Naturwissenschaften60, 399 (1973).PubMedGoogle Scholar
  8. 9.
    B. Rosenberg, Cancer Chemother. Rep.59, 589 (1975).PubMedGoogle Scholar
  9. 10.
    J. A. Howle and G. R. Gale, Biochem. Pharmac.19, 2757 (1970).Google Scholar
  10. 11.
    H. C. Harder and B. Rosenberg, Int. J. Cancer6, 207 (1970).PubMedGoogle Scholar
  11. 12.
    G. R. Gale, in: Platinum compounds in antineoplastic and immunosuppressive agents, vol.2, p. 829. Ed. A. C. Sartorelli and D. G. Johns. Academic Press New York 1975.Google Scholar
  12. 13.
    L. L. Munchausen, Proc. Nat. Acad. Sci. USA71, 4519 (1974).PubMedGoogle Scholar
  13. 14.
    J. Davidson, P. Faber and R. Fischer. Cancer Chemother. Rep.59, 287 (1975).PubMedGoogle Scholar
  14. 15.
    P. D. Braddock, T. A. Connors, M. Jones, A. R. Khornar, D. H. Melzack and M. L. Tobe, Chem. Biol. Int.11, 145 (1975).Google Scholar
  15. 16.
    S. Venitt and L. S. Levy, Nature250, 493 (1974).PubMedGoogle Scholar
  16. 17.
    B. J. Bachmann, Bacteriol. Rev.36, 525 (1972).PubMedGoogle Scholar
  17. 18.
    P. De Lucia and Cairns, J. Nat.224, 1164 (1969).Google Scholar
  18. 19.
    J. McCann, N. E. Spingarn, J. Kobori and B. N. Ames, Proc. Nat. Acad. Sci. USA72, 979 (1975).PubMedGoogle Scholar
  19. 20.
    J. Kleinberg, in: Inorganic synthesis, vol. 7 p. 241. Ed. Mc Graw Hill, New York 1963.Google Scholar
  20. 21.
    B. D. Davis and E. S. Mingioli, J. Bacteriol.60, 17 (1950).PubMedGoogle Scholar
  21. 22.
    V. W. Mayer, M. G. Gabridge and E. J. Osvald, Appl. Microbiol.18, 697 (1969).PubMedGoogle Scholar
  22. 23.
    B. N. Ames, F. D. Lee and W. E. Durston, Proc. Acad. Sci. USA70, 782 (1973).Google Scholar
  23. 24.
    H. J. Vogel and D. M. Bonner, J. biol. Chem.218, 97 (1956).PubMedGoogle Scholar
  24. 25.
    T. A. Connors, FEBS Letters57, 223 (1975).PubMedGoogle Scholar
  25. 26.
    B. Heinemann, in: Chemical mutagens. Ed. A. Hollander. Plenum Press, New York 1971.Google Scholar

Copyright information

© Birkhäuser Verlag 1977

Authors and Affiliations

  • M. Tamaro
    • 1
  • S. Venturini
    • 1
  • C. Eftimiadi
    • 1
  • C. Monti-Bragadin
    • 1
  1. 1.Institute of MicrobiologyUniversity of TriesteTrieste(Italy)

Personalised recommendations