Abstract
An increasing number of observations indicate that prostaglandin synthesis inhibition is not a satisfactory explanation for the antinociceptive activity of the non-steroidal anti-inflammatory drugs.
In the hot-plate test performed 1 or 2 h after ketorolac at 40, 70 and 100 mg/kg i.p., the drug does not display any significant antinociceptive activity. Nor, at the two higher doses used, does it affect the cortical and pontine serotonin binding capacity of rat brain membranes 2 h after treatment. The data suggest that this lack of antinociceptive activity in the hot-plate test is associated with the drug's inability to affect the central serotoninergic system.
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Vitale, G., Sandrini, M. & Pini, L.A. Lack of activity of ketorolac in hot-plate test and serotonin binding capacity of brain membranes in rats. Agents and Actions 41, 184–187 (1994). https://doi.org/10.1007/BF02001914
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DOI: https://doi.org/10.1007/BF02001914