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Annals of Vascular Surgery

, Volume 4, Issue 2, pp 171–178 | Cite as

Implant site: A determinant of completeness of arterial prosthesis healing in the dog and possibly in humans

  • Keith R. Durante
  • Hong-De Wu
  • Lester R. Sauvage
  • Qun Shi
  • Arlene R. Wechezak
  • Daniel E. Coan
  • Svetlana Kaplan
  • Malay D. Patel
  • Mark W. Walker
Original Articles
  • 6 Downloads

Abstract

This paper compares the healing of supported knitted Dacron prostheses implanted in the descending thoracic aorta and in the subcutaneous carotid-femoral positions in each of 10 dogs. The descending thoracic aorta prostheses were 6 cm long and the carotid-femoral prostheses averaged 76 cm in length. The healing of four porous clinical axillofemoral grafts is compared to that of the experimental carotid-femoral grafts. There was little similarity between the healing observed in the descending thoracic aortic and subcutaneous positions; the descending thoracic aorta grafts healed rapidly and completely by eight weeks, with thrombus-free flow surfaces covered with confluent endothelial cells. However, the inner wall of the carotidfemoral grafts remained largely unhealed at one year, with endothelialization largely confined to a limited pannus ingrowth across the anastomoses. This indicates that the implant site in the dog is a primary determinant of the rapidity and completeness of healing. The clinical axillofemoral grafts explanted after 20 months to six and one-half years exhibited healing characteristics that were similar to those seen in the carotid-femoral position in the dog. These findings suggest that valid comparisons of interspecies healing require data obtained from similar implant locations. They present a challenge to the previously held concepts of major interspecies differences in speed and extent of tissue ingrowth based on data obtained from noncomparable implant sites.

Key Words

Arterial prostheses long-length arterial prostheses axillofemoral grafts carotid-femoral grafts interspecies healing comparisons 

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References

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Copyright information

© Annals of Vascular Surgery Inc 1990

Authors and Affiliations

  • Keith R. Durante
    • 1
  • Hong-De Wu
    • 1
  • Lester R. Sauvage
    • 1
  • Qun Shi
    • 1
  • Arlene R. Wechezak
    • 1
  • Daniel E. Coan
    • 1
  • Svetlana Kaplan
    • 1
  • Malay D. Patel
    • 1
  • Mark W. Walker
    • 1
  1. 1.From The Hope Heart Institute, Providence Medical Center, and the Department of SurgeryUniversity of WashingtonSeattle

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