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European Journal of Pediatrics

, Volume 153, Issue 1, pp 23–27 | Cite as

Disseminated cat-scratch disease: Detection ofRochalimaea henselae in affected tissue

  • Katharina Waldvogel
  • Russell L. Regnery
  • Burt E. Anderson
  • Rosmarie Caduff
  • Jürg Caduff
  • David Nadal
Infectious Diseases Original Paper

Abstract

An immunocompetent 9-year-old boy with disseminated catscratch disease involving spleen, cervical and abdominal lymph nodes, skull, and one clavicle is reported. Antibodies toRochalimaea quintana andR. henselae were detected, at increasing, then decreasing concentration. DNA extracted from the biopsied skull lesion was amplified by polymerase chain reaction and hybridized with species-specific oligonucleotides proving the presence ofR. henselae in affected tissue. Our findings suggest thatR. henselea plays a pathogenic role in cat-scratch disease.

Key words

Cat-scratch diseaseRochalimaea henselae Rochalimaea quintana Serology Diagnosis 

Abbreviations

CSD

cat-scratch disease

PCR

polymerase chain reaction

RH1

Rochalimaea henselae 1 (oligonucleotide)

RQ1

Rochalimaea quintana 1 (oligonucleotide)

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Copyright information

© Springer-Verlag 1994

Authors and Affiliations

  • Katharina Waldvogel
    • 1
  • Russell L. Regnery
    • 4
  • Burt E. Anderson
    • 4
  • Rosmarie Caduff
    • 3
  • Jürg Caduff
    • 2
  • David Nadal
    • 1
  1. 1.Division of Immunology/HaematologyUniversity Children's HospitalZurichSwitzerland
  2. 2.Division of Paediatric RadiologyUniversity Hospital of ZurichZurichSwitzerland
  3. 3.Department of Clinical PathologyUniversity Hospital of ZurichZurichSwitzerland
  4. 4.Division of Viral and Rickettsial Diseases, National Center for Infectious DiseasesCenters for Diseases Control and PreventionAtlantaUSA

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