Abstract
Diphosphonates are known to affect calcium metabolism. It was therefore felt of interest to investigate the effects of SR 41319, a new Diphosphonate, comparatively to Etidronate disodium (EHDP) on Passive Cutaneous Anaphylaxis (PCA) and on Phospholipase A2 (PLA2) activity which are both mediated by calcium-dependent mechanisms. Results showed that: (1) intravenously, SR 41319 induced a dose-dependent inhibition of PCA more pronounced than the EHDP one; (2) in PLA2 assay, marked inhibition was obtained with SR 41319 whereas EHDP was slightly active. Decrease in Ca entry into mast cells and anti-PLA2 activity of SR 41319 might partly explain the SR 41319 inhibition of PCA.
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E. De Vries, J.P. Van Der Weij, C.I.P. Van Der Veen, H.C. Van Paassen, M.J. Jager, H.P. Sleeboom, D.L.M. Bijvoet andA. Cats,In vitro effect of (3-amino-1-hydroxypropylidene)-1,1-biphosphonic acid (APD) on the function of mononuclear phagocytes in lymphocyte proliferation, Immunology47, 157–163 (1982).
E. Bitteau andF. Hertz,Anaphylaxie cutanée passive chez le rat. Mise en évidence d'une substance protectrice, J. Pharmacol.10 (1), 69–72 (1979).
T.K. Bills, J.B. Smith andM.J. Silver,Selective release of arachidonic acid from the phospholipids of human platelets in response to thrombin. J. Clin. Invest.60, 1–6 (1977).
J.C. Foreman andL.G. Garland,Cromoglycate and other anti-allergic drugs; a possible mechanism of action, Br. Med. J.1, 820–821 (1976).
P. Vadas, S. Wasi, H.Z. Movat andJ.B. Hay,Extracellular phospholipase A 2 mediates inflammatory hyperaemia, Nature, Lond.293, 583–585 (1981).
E. Vallee andJ.F. Delahayes,Role of phospholipase A 2 in inflammation and aggregation. Interest of inhibitors, Eur. J. Rheumatol. Inflam.1, 300–304 (1978).
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Barbier, A., Breliere, J.C., Paul, R. et al. Comparative study of etidronate and SR 41319, a new diphosphonate, on passive cutaneous anaphylaxis and phospholipase A2 activity. Agents and Actions 16, 41–42 (1985). https://doi.org/10.1007/BF01999641
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DOI: https://doi.org/10.1007/BF01999641