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, Volume 16, Issue 1–2, pp 41–42 | Cite as

Comparative study of etidronate and SR 41319, a new diphosphonate, on passive cutaneous anaphylaxis and phospholipase A2 activity

  • A. Barbier
  • J. C. Breliere
  • R. Paul
  • R. Roncucci
Immediate Hypersensitivity


Diphosphonates are known to affect calcium metabolism. It was therefore felt of interest to investigate the effects of SR 41319, a new Diphosphonate, comparatively to Etidronate disodium (EHDP) on Passive Cutaneous Anaphylaxis (PCA) and on Phospholipase A2 (PLA2) activity which are both mediated by calcium-dependent mechanisms. Results showed that: (1) intravenously, SR 41319 induced a dose-dependent inhibition of PCA more pronounced than the EHDP one; (2) in PLA2 assay, marked inhibition was obtained with SR 41319 whereas EHDP was slightly active. Decrease in Ca entry into mast cells and anti-PLA2 activity of SR 41319 might partly explain the SR 41319 inhibition of PCA.


Calcium Mast Cell Disodium Etidronate Calcium Metabolism 
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Copyright information

© Birkhäuser Verlag 1985

Authors and Affiliations

  • A. Barbier
    • 1
  • J. C. Breliere
    • 1
  • R. Paul
    • 1
  • R. Roncucci
    • 1
  1. 1.Centre de Recherches CLIN-MIDYSANOFIMontpellier CedexFrance

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