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, Volume 16, Issue 1–2, pp 41–42 | Cite as

Comparative study of etidronate and SR 41319, a new diphosphonate, on passive cutaneous anaphylaxis and phospholipase A2 activity

  • A. Barbier
  • J. C. Breliere
  • R. Paul
  • R. Roncucci
Immediate Hypersensitivity

Abstract

Diphosphonates are known to affect calcium metabolism. It was therefore felt of interest to investigate the effects of SR 41319, a new Diphosphonate, comparatively to Etidronate disodium (EHDP) on Passive Cutaneous Anaphylaxis (PCA) and on Phospholipase A2 (PLA2) activity which are both mediated by calcium-dependent mechanisms. Results showed that: (1) intravenously, SR 41319 induced a dose-dependent inhibition of PCA more pronounced than the EHDP one; (2) in PLA2 assay, marked inhibition was obtained with SR 41319 whereas EHDP was slightly active. Decrease in Ca entry into mast cells and anti-PLA2 activity of SR 41319 might partly explain the SR 41319 inhibition of PCA.

Keywords

Calcium Mast Cell Disodium Etidronate Calcium Metabolism 

References

  1. [1]
    E. De Vries, J.P. Van Der Weij, C.I.P. Van Der Veen, H.C. Van Paassen, M.J. Jager, H.P. Sleeboom, D.L.M. Bijvoet andA. Cats,In vitro effect of (3-amino-1-hydroxypropylidene)-1,1-biphosphonic acid (APD) on the function of mononuclear phagocytes in lymphocyte proliferation, Immunology47, 157–163 (1982).PubMedGoogle Scholar
  2. [2]
    E. Bitteau andF. Hertz,Anaphylaxie cutanée passive chez le rat. Mise en évidence d'une substance protectrice, J. Pharmacol.10 (1), 69–72 (1979).Google Scholar
  3. [3]
    T.K. Bills, J.B. Smith andM.J. Silver,Selective release of arachidonic acid from the phospholipids of human platelets in response to thrombin. J. Clin. Invest.60, 1–6 (1977).PubMedGoogle Scholar
  4. [4]
    J.C. Foreman andL.G. Garland,Cromoglycate and other anti-allergic drugs; a possible mechanism of action, Br. Med. J.1, 820–821 (1976).PubMedGoogle Scholar
  5. [5]
    P. Vadas, S. Wasi, H.Z. Movat andJ.B. Hay,Extracellular phospholipase A 2 mediates inflammatory hyperaemia, Nature, Lond.293, 583–585 (1981).Google Scholar
  6. [6]
    E. Vallee andJ.F. Delahayes,Role of phospholipase A 2 in inflammation and aggregation. Interest of inhibitors, Eur. J. Rheumatol. Inflam.1, 300–304 (1978).Google Scholar

Copyright information

© Birkhäuser Verlag 1985

Authors and Affiliations

  • A. Barbier
    • 1
  • J. C. Breliere
    • 1
  • R. Paul
    • 1
  • R. Roncucci
    • 1
  1. 1.Centre de Recherches CLIN-MIDYSANOFIMontpellier CedexFrance

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