Comparative study of etidronate and SR 41319, a new diphosphonate, on passive cutaneous anaphylaxis and phospholipase A2 activity
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Diphosphonates are known to affect calcium metabolism. It was therefore felt of interest to investigate the effects of SR 41319, a new Diphosphonate, comparatively to Etidronate disodium (EHDP) on Passive Cutaneous Anaphylaxis (PCA) and on Phospholipase A2 (PLA2) activity which are both mediated by calcium-dependent mechanisms. Results showed that: (1) intravenously, SR 41319 induced a dose-dependent inhibition of PCA more pronounced than the EHDP one; (2) in PLA2 assay, marked inhibition was obtained with SR 41319 whereas EHDP was slightly active. Decrease in Ca entry into mast cells and anti-PLA2 activity of SR 41319 might partly explain the SR 41319 inhibition of PCA.
KeywordsCalcium Mast Cell Disodium Etidronate Calcium Metabolism
- E. De Vries, J.P. Van Der Weij, C.I.P. Van Der Veen, H.C. Van Paassen, M.J. Jager, H.P. Sleeboom, D.L.M. Bijvoet andA. Cats,In vitro effect of (3-amino-1-hydroxypropylidene)-1,1-biphosphonic acid (APD) on the function of mononuclear phagocytes in lymphocyte proliferation, Immunology47, 157–163 (1982).PubMedGoogle Scholar
- E. Bitteau andF. Hertz,Anaphylaxie cutanée passive chez le rat. Mise en évidence d'une substance protectrice, J. Pharmacol.10 (1), 69–72 (1979).Google Scholar
- P. Vadas, S. Wasi, H.Z. Movat andJ.B. Hay,Extracellular phospholipase A 2 mediates inflammatory hyperaemia, Nature, Lond.293, 583–585 (1981).Google Scholar
- E. Vallee andJ.F. Delahayes,Role of phospholipase A 2 in inflammation and aggregation. Interest of inhibitors, Eur. J. Rheumatol. Inflam.1, 300–304 (1978).Google Scholar