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, Volume 16, Issue 1–2, pp 41–42 | Cite as

Comparative study of etidronate and SR 41319, a new diphosphonate, on passive cutaneous anaphylaxis and phospholipase A2 activity

  • A. Barbier
  • J. C. Breliere
  • R. Paul
  • R. Roncucci
Immediate Hypersensitivity

Abstract

Diphosphonates are known to affect calcium metabolism. It was therefore felt of interest to investigate the effects of SR 41319, a new Diphosphonate, comparatively to Etidronate disodium (EHDP) on Passive Cutaneous Anaphylaxis (PCA) and on Phospholipase A2 (PLA2) activity which are both mediated by calcium-dependent mechanisms. Results showed that: (1) intravenously, SR 41319 induced a dose-dependent inhibition of PCA more pronounced than the EHDP one; (2) in PLA2 assay, marked inhibition was obtained with SR 41319 whereas EHDP was slightly active. Decrease in Ca entry into mast cells and anti-PLA2 activity of SR 41319 might partly explain the SR 41319 inhibition of PCA.

Keywords

Calcium Mast Cell Disodium Etidronate Calcium Metabolism 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Birkhäuser Verlag 1985

Authors and Affiliations

  • A. Barbier
    • 1
  • J. C. Breliere
    • 1
  • R. Paul
    • 1
  • R. Roncucci
    • 1
  1. 1.Centre de Recherches CLIN-MIDYSANOFIMontpellier CedexFrance

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