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Comparative study of etidronate and SR 41319, a new diphosphonate, on passive cutaneous anaphylaxis and phospholipase A2 activity

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Abstract

Diphosphonates are known to affect calcium metabolism. It was therefore felt of interest to investigate the effects of SR 41319, a new Diphosphonate, comparatively to Etidronate disodium (EHDP) on Passive Cutaneous Anaphylaxis (PCA) and on Phospholipase A2 (PLA2) activity which are both mediated by calcium-dependent mechanisms. Results showed that: (1) intravenously, SR 41319 induced a dose-dependent inhibition of PCA more pronounced than the EHDP one; (2) in PLA2 assay, marked inhibition was obtained with SR 41319 whereas EHDP was slightly active. Decrease in Ca entry into mast cells and anti-PLA2 activity of SR 41319 might partly explain the SR 41319 inhibition of PCA.

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Authors and Affiliations

  1. Centre de Recherches CLIN-MIDY, SANOFI, Avenue du Pr. J. Blayac, 34082, Montpellier Cedex, France

    A. Barbier, J. C. Breliere, R. Paul & R. Roncucci

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  1. A. Barbier
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  2. J. C. Breliere
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  3. R. Paul
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  4. R. Roncucci
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Barbier, A., Breliere, J.C., Paul, R. et al. Comparative study of etidronate and SR 41319, a new diphosphonate, on passive cutaneous anaphylaxis and phospholipase A2 activity. Agents and Actions 16, 41–42 (1985). https://doi.org/10.1007/BF01999641

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  • DOI: https://doi.org/10.1007/BF01999641

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