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An investigation of the involvement of platelet activating factor in the non-histamine immediate hypersensitivity reaction in the rat peritoneal cavity

  • Immediate Hypersensitivity
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Abstract

Synthetic PAF-acether injected intraperitoneally (i.p.) into sham-sensitized rats, caused dose-dependent extravasation of plasma proteins into the peritoneal fluids. Platelet aggregating activity was detected in the peritoneal fluids. In rats that had been passively sensitized for a non-histamine mediated immediate hypersensitivity reaction, antigen challenge caused extravasation of plasma proteins into the peritoneal fluids. No platelet aggregating activity was detected in these fluids. PAF is unlikely to be the mediator of extravasation in the non-histamine mediated immediate hypersensitivity reaction in the rat.

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References

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  3. J.W. Ross, B. Nunn andB.A. Spicer,The involvement of platelet activating factor in the non-histamine immediate hypersensitivity reaction in the rat peritoneal cavity, in preparation.

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Authors and Affiliations

  1. Beecham Pharmaceuticals Research Division, Biosciences Research Centre, Great Burgh, Yew Tree Bottom Road, KT18 5XQ, Epsom, Surrey, UK

    B. A. Spicer, J. W. Ross & B. Nunn

Authors
  1. B. A. Spicer
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  2. J. W. Ross
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  3. B. Nunn
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Spicer, B.A., Ross, J.W. & Nunn, B. An investigation of the involvement of platelet activating factor in the non-histamine immediate hypersensitivity reaction in the rat peritoneal cavity. Agents and Actions 16, 36 (1985). https://doi.org/10.1007/BF01999638

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  • DOI: https://doi.org/10.1007/BF01999638

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