Lymphocyte migration in the mouse II. Differential B and T-lymphocyte migration into a site of chronic inflammation
Different patterns of B and T-lymphocyte migration were observed in normal mice and in animals with a site of chronic inflammation. The early migration of lymphocytes into a site of chronic inflammation, induced by sensitisation and challenge toBordatella pertussis vaccine (BPV), comprised mainly B-cells. Subsequently, a greater influx of T-cells occured as the inflammation progressed. The lymphocyte population in the inflammatory exudate was composed of equal numbers of B and T-cells throughout the 30 day time course. Preferential migration of B-cells to Peyer's patches (PP) and T-cells to peripheral lymph nodes (PLN) occured in both normal mice and animals with a site of chronic inflammation. In contrast, B-cells migrated preferentially to the spleen in normal mice while in mice with chronic inflammation a greater migration of T-cell was observed. These findings indicate the presence of homing receptors for PP on B-cells and of PLN homing receptors on T-cells, with their distribution unaffected during the development of the inflammatory response. In contrast, the inflammatory process did alter the type of cell migrating into the spleen which may reflect an increase in antigen presentation in the mice challenged with BPV.
KeywordsInflammatory Response Inflammatory Process Chronic Inflammation Pertussis Antigen Presentation
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- E. C. Butcher and I. L. Weissman,Cellular, genetic and evolutionary aspects of lymphocyte interactions with high-endothelial venules. InBlood cells and vessel walls; functional interactions. CIBA Foundation Symposium71, pp. 265–281, Excerpta Medica, Amsterdam 1980.Google Scholar
- J. J. Woodruff, L. M. Clark and Y. H. Chin,Specific cell-ad hesion mechanisms determining migration pathways of recd culating lymphocytes. Ann. Rev. Immunol.5, 201–222 (1987).Google Scholar
- D. M. V. Parrott and A. Ferguson,Selective migration of lymphocytes within the mouse small intestine. Immunol.26, 571–588 (1974).Google Scholar
- M. L. Rose, D. M. V. Parrott and G. R. Bruce,Migration of lymphocytes to the small intestine. I. Effect of Trichinella spiralis infection on the migration of mesenteric lymphoblasts and mesenteric T lymphoblasts in syngeneic mice. Immunol31, 723–730 (1976).Google Scholar