Advertisement

Agents and Actions

, Volume 35, Issue 3–4, pp 252–259 | Cite as

Lymphocyte migration in the mouse II. Differential B and T-lymphocyte migration into a site of chronic inflammation

  • J. Dawson
  • A. D. Sedgwick
  • J. C. W. Edwards
  • P. Lees
Inflammation and Immunomodulation

Abstract

Different patterns of B and T-lymphocyte migration were observed in normal mice and in animals with a site of chronic inflammation. The early migration of lymphocytes into a site of chronic inflammation, induced by sensitisation and challenge toBordatella pertussis vaccine (BPV), comprised mainly B-cells. Subsequently, a greater influx of T-cells occured as the inflammation progressed. The lymphocyte population in the inflammatory exudate was composed of equal numbers of B and T-cells throughout the 30 day time course. Preferential migration of B-cells to Peyer's patches (PP) and T-cells to peripheral lymph nodes (PLN) occured in both normal mice and animals with a site of chronic inflammation. In contrast, B-cells migrated preferentially to the spleen in normal mice while in mice with chronic inflammation a greater migration of T-cell was observed. These findings indicate the presence of homing receptors for PP on B-cells and of PLN homing receptors on T-cells, with their distribution unaffected during the development of the inflammatory response. In contrast, the inflammatory process did alter the type of cell migrating into the spleen which may reflect an increase in antigen presentation in the mice challenged with BPV.

Keywords

Inflammatory Response Inflammatory Process Chronic Inflammation Pertussis Antigen Presentation 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. [1]
    E. C. Butcher and I. L. Weissman,Cellular, genetic and evolutionary aspects of lymphocyte interactions with high-endothelial venules. InBlood cells and vessel walls; functional interactions. CIBA Foundation Symposium71, pp. 265–281, Excerpta Medica, Amsterdam 1980.Google Scholar
  2. [2]
    E. C. Butcher, R. G. Scollay and I. L. Weissman,Organ specificity of lymphocyte migration: Mediation by highly selective lymphocyte interaction with organ-specific determinants. Eur. J. Immunol.10, 556–561 (1980).PubMedGoogle Scholar
  3. [3]
    H. B. Stamper and J. J. Woodruff,Lymphocyte homing into lymph nodes: In vitro demonstration of the selective affinity of recirculating lymphocytes for high endothelial venules. J. Exp. Med.144, 828–833 (1976).PubMedGoogle Scholar
  4. [4]
    H. B. Stamper and J. J. Woodruff,An in vitro model of lymphocyte homing. 1. Characterisation of the interaction between thoracic duct lymphocytes and specialised high endothelial venules of lymph nodes. J. Immunol.119, 772–780 (1977).PubMedGoogle Scholar
  5. [5]
    S. K. Stevens, I. L. Weissman and E. C. Butcher,Differences in the migration of B and T lymphocytes: Organ-selective localisation in vivo and the role of lymphocyte-endothelial cell recognition. J. Immunol.128, 844–851 (1982).PubMedGoogle Scholar
  6. [6]
    G. Kraal, A. Twisk, B. Tan and R. Scheper,A surface binding molecule on guinea-pig lymphocytes involved in adhesion and homing. Eur. J. Immunol.16, 1515–1519 (1986).PubMedGoogle Scholar
  7. [7]
    J. J. Woodruff, L. M. Clark and Y. H. Chin,Specific cell-ad hesion mechanisms determining migration pathways of recd culating lymphocytes. Ann. Rev. Immunol.5, 201–222 (1987).Google Scholar
  8. [8]
    J. Dawson, A. D. Sedgwick, J. C. W. Edwards and P. Lees,Lymphocyte migration in the mouse. I. Time course of cell accumulation and the effect of antigen sensititisation and challenge. Agents and Actions35, 245–251 (1992).PubMedGoogle Scholar
  9. [9]
    P. Miossec, C.-L. Yu and M. Ziff,Lymphocyte chemotactic activity of human interleukin 1. J. Immunol.133, 2007–2011 (1984).PubMedGoogle Scholar
  10. [10]
    D. A. Willoughby,The mechanisms of cutaneous hypersensitivity in the rat and its suppression by immunological methods. J. Path.92, 139–150 (1966).PubMedGoogle Scholar
  11. [11]
    T. E. Halstead and J. H. Hall,The homing of lymph-borne immunoblasts to the small gut of neonatal rats. Transplantation14, 339–346 (1972).PubMedGoogle Scholar
  12. [12]
    D. M. V. Parrott and A. Ferguson,Selective migration of lymphocytes within the mouse small intestine. Immunol.26, 571–588 (1974).Google Scholar
  13. [13]
    M. L. Rose, D. M. V. Parrott and G. R. Bruce,Migration of lymphocytes to the small intestine. I. Effect of Trichinella spiralis infection on the migration of mesenteric lymphoblasts and mesenteric T lymphoblasts in syngeneic mice. Immunol31, 723–730 (1976).Google Scholar
  14. [14]
    A. J. Husband and J. L. Gowans,The origin and antigen pendent distribution of IgA-containing cells in the intestine Exp. Med.148, 1146–1160 (1978).PubMedGoogle Scholar
  15. [15]
    G. Kraal and A. Twisk,The itneraction of high endothelia venules with T and B cells in peripheral lymph nodes after antigenic stimulation. Eur. J. Immunol.14, 586–588 (1984).PubMedGoogle Scholar

Copyright information

© Birkhäuser Verlag 1992

Authors and Affiliations

  • J. Dawson
    • 1
  • A. D. Sedgwick
    • 2
  • J. C. W. Edwards
    • 3
  • P. Lees
    • 1
  1. 1.Department of Pharmacology, Royal Veterinary CollegeUniversity of LondonHatfieldUK
  2. 2.Department of Anti-inflammatory BiologyRoche Products Ltd.Welwyn Garden CityUK
  3. 3.Department of RheumatologyUniversity College and Middlesex School of MedicineLondonUK

Personalised recommendations