Abstract
In a double-blind, randomized, comparative study, 101 atients subjected to natural events like insect bites or solar erythemas were treated locally with either dimethindene (DIM) gel (n=49) or placebo (PLA) gel (n=52). Mosquito bites were the most frequent incidents. Efficacy assessment was based on the speed of disappearance of itching. When only the first event is taken into account, 43 out of 49 patients (88%) treated with DIM were relieved from itching within 30 min of the gel application. The corresponding figures for PLA were 33/52 (64$) (p=<0.01). For all events (n=226) the results gave 85/101 (84%) cases relieved for DIM and 82/125 (66%) for PLA (p=<0.01). Only minor and transient side-effects were notified in either group. In these everyday life conditions, DIM gel was shown to relieve ruritus more quickly than PLA, especially in mosquito-bitten patients.
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References
D. Rehn, H. Geissler, U. Schönbrunn, H. Lukas and G. Hennings,Effect-time relation of the H 1-receptor antagonist dimethindene maleafe following intravenous injection. Agents and Actions30, 178–181 (1990).
R. Kiehn and J. Rakoski,FENISTIL Retard versus HISMANAL in patients with chronic itching dermatoses. Allergologie11, 512–515 (1987).
H. Bibi, R. Drachman, N. Sharon, Y. Schwartz, M. Schlesinger, S. Pollak and P. A. Vardy,Dimethpyrindene maleate in the treatment of recurrent spasmodic group. Drugs Exp. Clin. Res.10(2), 141–145 (1984).
P. I. Gumowski, E. J. Vandierendounck, P. Grosgurin and J. P. Girard,Essai comparatif entre le dimétindéne et la clémastine par voie, intraveineuse dans le choc anaphylactique. Méd. et Hyg.43 (1623), 2682–2688 (1985).
B. Zimmermann and H. Fisher,Antipruriginöse bzw. antiallergische Therapie. Zur Wirksamkeit und Verträglichkeit von Dimetindenmaleat in intravenöser Verabreichung. Fortschr. Med.99 (35), 1418–1420 (1981).
L. R. Lever, S. Hills, P. J. Dykes and R. Marks,Efficacy of topical dimethindene in experimentally induced pruritus and weal and flare reactions, Skin Pharmacol.4, 109–112 (1991).
F. Humphreys and S. Shuster,The effect of topical dimethindene maleate on weal reactions. Br. J. Clin. Pharmacol.23, 234–236 (1987).
B. Spilker,Clinical evaluation of topical antiprutitics and antihistamines. Models Dermatol.3, 55–61 (1987).
B. Spilker, R. D. Wilkins and J. G. Perkins,A novel doubleblind method to evaluate topically applied antipruritic drugs. Cur. Ther. Res.35 (4), 593–605 (1984).
R. Kiehn,Aktuelle Therapie der Mückenstichallergie.Sozialpädiatrie in Praxis und Klinik 8 (8), 579–581 (1986).
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Althaus, M.A., Berthet, P. Dimethindene maleate (Fenistil Gel) in the control of itching due to insect bites and sunburns. Agents and Actions 36 (Suppl 2), C425–C427 (1992). https://doi.org/10.1007/BF01997391
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DOI: https://doi.org/10.1007/BF01997391